Acute effect of infection by adipogenic human adenovirus Ad36.

Abstract:

:Human adenovirus Ad36 is causally and correlatively associated in animals and humans, respectively, with increased adiposity and altered metabolic profile. We inoculated rats with Ad36 or UV-inactivated Ad36, or mock-infected them. Four days later, Ad36-infected rats showed 23% greater epididymal fat pad weight and viral mRNA; the viral DNA could also be detected in tissues viz. the liver, brain, and adipose tissue. Intranasal or intra-peritoneal routes of viral inoculation showed similar tissue affinity. The serum cytokine response was markedly down-regulated. Ad36 acutely suppresses the systemic immune response and spreads widely. This information will help to determine Ad36 tissue tropism and its metabolic consequences.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Pasarica M,Loiler S,Dhurandhar NV

doi

10.1007/s00705-008-0219-2

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

2097-102

issue

11

eissn

0304-8608

issn

1432-8798

journal_volume

153

pub_type

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