Genome type analysis of South American adenoviruses of subgenus C collected over a 7-year period.

Abstract:

:A collection of 148 adenovirus strains of subgenus C collected in Argentina, Chile, and Uruguay were studied by restriction enzyme analysis of genomic DNA with endonucleases BamHI, BglII, BstEII, EcoRI, HindIII, KpnI, and SmaI. Only strains corresponding to serotypes 1, 2, and 5 were identified representing both already described and new genome types. The most frequently detected type was Ad 2 followed by Ad 1 and Ad 5. Three different genomic variants of both Ad 1 and Ad 5 were discriminated. Ad 2 with 9 genome types exhibited the greatest variability. Novel profiles emerged only in strains corresponding to this serotype by restriction with BglII and BstEII. The circulation of prototype-like strains of Ad 1 throughout the study period is note-worthy. Thirty-six of 43 strains corresponded to genome type D 1. Clearly, one genome type of each serotype predominated over the 7-year period (Ad 1 D 1, n = 36; Ad 2 D 5, n = 32, Ad 5 D 36, n = 17). Some genomic variants were detected sporadically and only in Argentina, Chile, or Uruguay whereas others were widely distributed and circulated for years. A high proportion of the analysed strains was isolated from children under one year and males were more frequently infected than females.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Kajon AE,Suárez MV,Avendaño LF,Hortal M,Wadell G

doi

10.1007/BF01309841

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

29-35

issue

1-2

eissn

0304-8608

issn

1432-8798

journal_volume

132

pub_type

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