Inhibition of human immunodeficiency virus (HIV) type 1 multiplication by an avian cellular factor.

Abstract:

:A factor secreted from avian cells infected non productively with a non cytopathogenic mutant of vesicular stomatitis virus (VSV ts 1026) interferes with HIV replication in CEM cells and peripheral blood monocytes (PBL). Production of infectious particles is decreased and many virions lack cores and/or spikes. In CEM cells the prmRNA is spliced into 7.5, 4, and 2 kb mRNA. Residual virus contains less env encoded proteins and p 18; p 25 appears as several bands. The processing of tat, rev. and nef proteins differs in treated cells and in controls.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Semmel M,Alileche A,Coulaud D,Aguilar J,Krief P,Jasmin C

doi

10.1007/BF01317266

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

309-21

issue

3-4

eissn

0304-8608

issn

1432-8798

journal_volume

123

pub_type

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