Characterization of echovirus 25 (ECV 25) in the VP1/2A gene junction region. Brief report.

Abstract:

:Genetic relationships among echovirus type 25 (ECV 25) isolates associated with aseptic meningitis in Germany 1997/98 and a 40-year-old ECV 25 prototype strain were investigated using RT-PCR and direct sequencing the VP1/2A gene junction region. Sequences were compared to each other and to non-polio enterovirus representatives (phylogenetic analysis). The analysis indicated that the sequences of recent isolates have drifted over time distinctly away from the prototype strain sequence. Genetic drift may change biological features of isolates possibly leading to new antigenic variants.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Künkel U,Schreier E

doi

10.1007/s007050050640

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

2253-8

issue

11

eissn

0304-8608

issn

1432-8798

pii

91442253.705

journal_volume

144

pub_type

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