Influence of cell cycle on HIV-1 expression differs among various models of chronic infection.

Abstract:

:Because of an inherent dependence on host cell second and third messenger signaling pathways for activation of HIV-1 expression, a potential exists for a relationship between the induction of latent HIV-1 and cell-cycle-related events. To investigate this potential relationship, cellular models of latent HIV-1 infection (OM-10.1 promyelocytes, ACH-2 T-lymphocytes, and U1 promonocytes) were chemically treated or gamma-irradiated to synchronize cultures at each cell cycle stage and then examined for constitutive and TNF-alpha-induced HIV-1 expression. Cell cycle synchronization alone had no effect on HIV-1 expression in OM-10.1 and U1 cultures; whereas enhanced constitutive HIV-1 expression was observed in ACH-2 cultures at G2 + M. A 2 hour TNF-alpha treatment of all synchronized OM-10.1 cultures activated HIV-1 expression to a similar extent as unsynchronized cultures. In contrast, the extent of TNF-alpha-induced HIV-1 expression in ACH-2 S and G2 + M cultures and in the U1 G0/G1 culture was greater than that in unsynchronized control cultures. However, no delay in the initial response was observed. Thus, the influence of cell cycle on constitutive and induced HIV-1 expression varied in each cellular model and, therefore, may further relate to the different molecular mechanisms maintaining viral latency.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Roberts BD,Fang G,Butera ST

doi

10.1007/s007050050144

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

1087-99

issue

6

eissn

0304-8608

issn

1432-8798

journal_volume

142

pub_type

杂志文章
  • Genetic structure and variability of tobacco vein banding mosaic virus populations.

    abstract::Tobacco vein banding mosaic virus (TVBMV) is of increasing importance in tobacco production. Knowledge of the genetic structure and variability of the virus population is vital for developing sustainable management. In this study, 24 new TVBMV isolates from Sichuan Province together with 46 previous isolates were stud...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-019-04342-6

    authors: Wei S,He X,Wang D,Xiang J,Yang Y,Yuan S,Shang J,Yang H

    更新日期:2019-10-01 00:00:00

  • Molecular characterization of the nucleocapsid protein gene of Newcastle disease virus strains in Japan and development of a restriction enzyme-based rapid identifying method.

    abstract::Nucleocapsid protein (NP) gene of Newcastle disease virus (NDV) strains mainly isolated in Japan from 1930 to 2001 was genetically characterized. By deduced amino acid sequence comparison, the N-terminal region (from 1 to 401 residues) of the NP protein was found to be highly conserved, while the C-terminal region was...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-004-0309-8

    authors: Pham HM,Chang KS,Mase M,Ohashi K,Onuma M

    更新日期:2004-08-01 00:00:00

  • Sequence analysis of the lymphotropic Aleutian disease parvovirus ADV-SL3.

    abstract::About 98% of the DNA sequence of the lymphotropic Aleutian disease parvovirus isolate ADV-SL3 was determined and analysed. The sequence revealed that this isolate was a type-1 ADV strain, supporting that the currently used typing of ADV viruses does not correlate with virulence or pathogenicity. ADV-SL3 had a very hig...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050050066

    authors: Schuierer S,Bloom ME,Kaaden OR,Truyen U

    更新日期:1997-01-01 00:00:00

  • Experimental parainfluenza virus infection in mice: growth and spread of a highly pathogenic variant of parainfluenza 3 virus in the mouse brain.

    abstract::We had previously showed that following intracerebral inoculation of newborn mice, the 910 N and M strains of bovine parainfluenza 3 virus induce a non-lethal hydrocephalus and a lethal disease with marked thymic and splenic atrophy, respectively. Moreover, only the M virus was lethal for 2-week-old mice. In the prese...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01310963

    authors: Shibuta H,Kanda T,Nozawa A,Sato S,Kumanishi T

    更新日期:1985-01-01 00:00:00

  • Genetic organisation of Iris yellow spot virus M RNA: indications for functional homology between the G(C) glycoproteins of tospoviruses and animal-infecting bunyaviruses.

    abstract::The complete nucleotide sequence (4838 nucleotides) of Iris yellow spot virus (IYSV) M RNA indicates, typical for tospoviruses, the presence of two genes in ambisense arrangement. The vRNA ORF codes for the potential cell-to-cell movement (NSm) protein (34.8 kDa) and the vcRNA ORF for the viral glycoprotein (G1/G2) pr...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-002-0885-4

    authors: Cortez I,Aires A,Pereira AM,Goldbach R,Peters D,Kormelink R

    更新日期:2002-12-01 00:00:00

  • Complete sequence and variability of a new subgroup B nepovirus infecting potato in central Peru.

    abstract::The complete bipartite genome (RNA1 and RNA2) of a new nepovirus infecting potato was obtained using small RNA sequencing and assembly complemented by Sanger sequencing. Each RNA encodes a single polyprotein, flanked by 5' and 3' untranslate regions (UTR) and followed by a poly (A) tail. The putative polyproteins enco...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-016-3147-6

    authors: De Souza J,Müller G,Perez W,Cuellar W,Kreuze J

    更新日期:2017-03-01 00:00:00

  • Direct evidence for genome segment reassortment between concurrently-circulating human rotavirus strains.

    abstract::Extensive heterogeneity in electropherotypes observed among group A human rotaviruses has been considered as a result of two major mechanisms; i.e., the accumulation of point mutations and genetic reassortment between concurrently-circulating strains. However, no evidence was reported thus far indicating that any one ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050170162

    authors: Watanabe M,Nakagomi T,Koshimura Y,Nakagomi O

    更新日期:2001-01-01 00:00:00

  • Molecular epidemiology of TTV-like mini virus in Norway.

    abstract::TT virus (TTV), the first human circovirus to be discovered, appears to be present in most people; less is known about the prevalence of the related TTV-like mini virus (TLMV). A sensitive nested PCR, specific for TLMV, detected the virus in 48% of 201 sera (Norwegian blood donors) previously found to have a 90% preva...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s705-002-8310-6

    authors: Moen EM,Huang L,Grinde B

    更新日期:2002-01-01 00:00:00

  • The complete genome sequence of Escherichia phage SRT7, a novel T7-like phage.

    abstract::In this study, we isolated a novel virulent Escherichia phage, SRT7. Its genome is a double-stranded linear DNA molecule containing 39,883 bp. Direct terminal repeats with a length of 175 bp, are present at both ends of the genome. The G+C content is 50.54%. Forty-seven putative protein coding genes were identified. N...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-019-04182-4

    authors: Zhao K,Song S,Zhao Z,Liu Z,Ji Y,Gu P,Fan X,Li Q

    更新日期:2019-04-01 00:00:00

  • Antiretroviral drug resistance mutations in the reverse transcriptase gene of HIV-1 isolates from Northern Indian patients: a follow-up study.

    abstract::The viral reverse transcriptase gene was amplified from the plasma of 27 drug-naïve and five drug-experienced HIV patients in Northern India. Follow-up samples of naïve patients after antiretroviral therapy initiation were collected in six patients at 3 months and three patients at 6 months. Phylogenetic analysis reve...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-010-0605-4

    authors: Dutta Choudhury S,Chaudhury AK,Kalra R,Andrabi R,Wig N,Biswas A,Bala M,Luthra K

    更新日期:2010-04-01 00:00:00

  • The sequence of the coxsackievirus A 21 polymerase gene indicates a remarkably close relationship to the polioviruses. Brief report.

    abstract::We have sequenced the coxsackievirus A 21 polymerase gene and 3' noncoding region. The sequence is 98 per cent homologous at the amino acid level to the three poliovirus serotypes. This is comparable to the relationship between polioviruses and indicates a recent evolutionary divergence of the viruses. ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01313732

    authors: Hughes PJ,Phillips A,Minor PD,Stanway G

    更新日期:1987-01-01 00:00:00

  • An emerging novel bovine coronavirus with a 4-amino-acid insertion in the receptor-binding domain of the hemagglutinin-esterase gene.

    abstract::The hemagglutinin-esterase (HE) protein of betacoronavirus lineage A is a secondary receptor in the infection process and is involved in the emergence of new betacoronavirus genotypes with altered host specificity and tissue tropism. We previously reported a novel recombinant bovine coronavirus (BCoV) strain that was ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-020-04840-y

    authors: Abi KM,Zhang Q,Zhang B,Zhou L,Yue H,Tang C

    更新日期:2020-12-01 00:00:00

  • Using small RNA sequences to diagnose, sequence, and investigate the infectivity characteristics of vegetable-infecting viruses.

    abstract::In a virus-infected plant, small interfering RNAs (siRNAs) corresponding to the viral genome form a large proportion of the small RNA population. It is possible to reassemble significant portions of the virus sequence from overlapping siRNA sequences and use these to identify the virus. We tested this technique with a...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-011-0979-y

    authors: Hagen C,Frizzi A,Kao J,Jia L,Huang M,Zhang Y,Huang S

    更新日期:2011-07-01 00:00:00

  • Herpes simplex virus type 1 infection in mice with severe combined immunodeficiency (SCID).

    abstract::Herpes simplex virus type 1 (HSV-1) infection in mutant mice with severe combined immunodeficiency (SCID mice), i.e., mice in which the differentiation of both T and B lymphocytes is severely impaired, was studied. All control (infected and not treated with antibodies or with immune spleen cells) SCID mice were dead b...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01319810

    authors: Minagawa H,Sakuma S,Mohri S,Mori R,Watanabe T

    更新日期:1988-01-01 00:00:00

  • Identification of a novel astrovirus in a domestic pig in Hungary.

    abstract::The family Astroviridae consists of two genera, Avastrovirus and Mamastrovirus, whose members are associated with gastroenteritis in avian and mammalian hosts, respectively. We serendipitously identified a novel porcine astrovirus in a fecal specimen from a domestic pig (Sus scrofa domestica) in Hungary. Sequencing of...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-010-0827-5

    authors: Reuter G,Pankovics P,Boros A

    更新日期:2011-01-01 00:00:00

  • Suppressor of RNA silencing encoded by the monopartite tomato leaf curl Java begomovirus.

    abstract::We previously isolated the monopartite begomovirus tomato leaf curl Java virus (ToLCJAV) and satellite DNAbeta02 from the same naturally infected tomato source in Indonesia. ToLCJAV induced mild leaf curl symptoms in Nicotiana benthamiana plants; DNAbeta02 encoded the betaC1 gene and produced severe leaf curl symptoms...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-007-0957-6

    authors: Kon T,Sharma P,Ikegami M

    更新日期:2007-01-01 00:00:00

  • Inhibition of hepatitis C virus adsorption to peripheral blood mononuclear cells by dextran sulfate.

    abstract::Human peripheral blood mononuclear cells (PBMC) can be infected in vitro with sera of hepatitis C virus (HCV)-infected patients. We have treated pools of PBMC with dextran sulfate MW 8,000, before infection with various HCV(+) sera. When the cells were treated with dextran sulfate 10-3 M, HCV RNA was no longer detecta...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050050293

    authors: Cribier B,Schmitt C,Kirn A,Stoll-Keller F

    更新日期:1998-01-01 00:00:00

  • Rose virus R, a cytorhabdovirus infecting rose.

    abstract::RNA was extracted from 'Hugh Dickson' rose leaves displaying virus-like symptoms in Maryland, USA. Using high-throughput sequencing, we identified a new virus, tentatively named "rose virus R". This virus has a negative-sense, single-stranded RNA genome and exhibits genomic features of a rhabdovirus, including a genom...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-020-04927-6

    authors: Bolus S,Al Rwahnih M,Grinstead SC,Mollov D

    更新日期:2021-01-04 00:00:00

  • Evidence for a bovine origin of the polyomavirus detected in foetal rhesus monkey kidney cells, FRhK-4 and -6.

    abstract::Rabbit antisera to the stump-tailed macaque polyomavirus (STMV) which had been shown by immunoelectron microscopy and indirect immunofluorescence to react with the polyomavirus found in FRhK-4 cells (FRKV), also gave precipitin lines in counter-immunoelectrophoresis (CIE) and double diffusion in gel (GD) when reacted ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01311311

    authors: Parry JV,Lucas MH,Richmond JE,Gardner SD

    更新日期:1983-01-01 00:00:00

  • DNA vaccination induces a long-term antibody response and protective immunity against pseudorabies virus in mice.

    abstract::In order to investigate the mechanism of long-term immunity and the effect of protective immunity induced by DNA vaccination, we constructed the expression plasmid containing a pseudorabies virus (PRV) gD gene encoding an envelope glycoprotein. Intramuscular vaccination of mice with the plasmid DNA induced a strong an...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050050272

    authors: Ho TY,Hsiang CY,Hsiang CH,Chang TJ

    更新日期:1998-01-01 00:00:00

  • Resistance to superinfection of Vero cells persistently infected with Junin virus.

    abstract::Two non-virogenic Vero cell lines persistently infected with the arenavirus Junin (JUNV), named V3 and V7, were characterized with respect to their resistance to superinfection with homologous and antigenically related viruses. Both lines were refractory to JUNV multiplication and partially resistant to other arenavir...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-003-0227-1

    authors: Ellenberg P,Edreira M,Scolaro L

    更新日期:2004-03-01 00:00:00

  • Guinea pig cytomegalovirus: transplacental transmission. Brief report.

    abstract::A well characterized strain of guinea pig cytomegalovirus (GPCMV) was used to infect pregnant guinea pigs during various periods of pregnancy. Transplacental transmission of virus with invasion of the fetus was observed, even in some mothers with preinoculation evidence of GPCMV antibody. Fetal infection occurred duri...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01317422

    authors: Johnson KP,Connor WS

    更新日期:1979-01-01 00:00:00

  • Genetic polymorphism across regions of the three open reading frames of "Norwalk-like viruses".

    abstract::Genomic characterization of Norwalk-like human caliciviruses (NLVs) originating from outbreaks and sporadic cases of acute gastroenteritis has revealed surprisingly high levels of diversity, even in the RNA polymerase gene, which is anticipated to be highly conserved. Since information on antigenic relationship is lim...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050050020

    authors: Vinjé J,Green J,Lewis DC,Gallimore CI,Brown DW,Koopmans MP

    更新日期:2000-01-01 00:00:00

  • The role of host immunocompetence in neuroinvasion of Sindbis virus.

    abstract::Viral infections of the central nervous system (CNS) following peripheral inoculation of Sindbis viruses were studied. The use of viral strains, which vary in their neuroinvasive and neurovirulent properties, and various strains of mice, which differ in immunocompetence, revealed several pathways of viral neuroinvasio...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050050576

    authors: Lustig S,Halevy M,Ben-Nathan D,Rice CM,Kobiler D

    更新日期:1999-01-01 00:00:00

  • Sequence variation in two genes determines the efficacy of transmission of citrus tristeza virus by the brown citrus aphid.

    abstract::Vector transmission is an important part of the viral infection cycle, yet for many viruses little is known about this process, or how viral sequence variation affects transmission efficacy. Here we examined the effect of substituting genes from the highly transmissible FS577 isolate of citrus tristeza virus (CTV) in ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-016-3070-x

    authors: Harper SJ,Killiny N,Tatineni S,Gowda S,Cowell SJ,Shilts T,Dawson WO

    更新日期:2016-12-01 00:00:00

  • Effectiveness of first-line antiretroviral therapy in HIV/AIDS patients: A 5-year longitudinal evaluation in Fujian Province, Southeast China.

    abstract::The aim of this study was to evaluate the long-term effectiveness of first-line antiretroviral therapy in HIV/AIDS patients in Southeast China. A total of 450 eligible patients were selected to initiate first-line antiretroviral therapy from February 2005 through August 2009. During the study period from 2009 through ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-015-2583-z

    authors: Wu S,Qiu Y,Yan P,Wang W,Xie M,Xia P,Wang Z,Yan Y

    更新日期:2015-11-01 00:00:00

  • VP1, the RNA-dependent RNA polymerase and genome-linked protein of infectious bursal disease virus, interacts with the carboxy-terminal domain of translational eukaryotic initiation factor 4AII.

    abstract::Infectious bursal disease virus (IBDV), a member of the family Birnaviridae, is a non-enveloped, double-stranded RNA virus. Viral protein 1 (VP1), the putative RNA-dependent RNA polymerase, occurs in virions both as a free polypeptide and as a genome-linked protein, called VPg. To gain more insight in its function, we...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-004-0365-0

    authors: Tacken MG,Thomas AA,Peeters BP,Rottier PJ,Boot HJ

    更新日期:2004-11-01 00:00:00

  • Characterization of viral DNAs from cells infected with chicken anaemia agent: sequence analysis of the cloned replicative form and transfection capabilities of cloned genome fragments.

    abstract::The viral DNAs induced by the unclassified animal virus, chicken anaemia agent (CAA), during replication in MDCC-MSB 1 cells have been investigated. Analyses after S1 nuclease, restriction endonuclease and denaturation treatments indicated that infected cell extracts contained genome-size, single-stranded DNA (M(r) 2....

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/BF01309811

    authors: Meehan BM,Todd D,Creelan JL,Earle JA,Hoey EM,McNulty MS

    更新日期:1992-01-01 00:00:00

  • Multiple hepatitis virus infections in chronic HBsAg carriers in Naples.

    abstract::In order to determine the prevalence of multiple infections with hepatitis viruses in chronic HBsAg carriers in Naples, to assess the interaction between HBV, HDV and HCV infections and to evaluate the influence of multiple virus hepatitis infections on the clinical presentation, we studied 198 HBsAg chronic carriers ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s007050050090

    authors: Sagnelli E,Felaco FM,Filippini P,Scolastico C,Rapicetta M,Stroffolini T,Piccinino F

    更新日期:1997-01-01 00:00:00

  • Antiviral activity of baicalin against influenza A (H1N1/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase.

    abstract::Scutellaria baicalensis Georgi, a Chinese herbal decoction, has been used for the treatment of the common cold, fever and influenza virus infections. In previous studies, we found that oral administration of baicalein resulted in the inhibition of influenza A virus replication in vivo, which was linked to baicalin in ...

    journal_title:Archives of virology

    pub_type: 杂志文章

    doi:10.1007/s00705-014-2192-2

    authors: Ding Y,Dou J,Teng Z,Yu J,Wang T,Lu N,Wang H,Zhou C

    更新日期:2014-12-01 00:00:00