Abstract：
:Herpes simplex virus type 1 (HSV-1) infection in mutant mice with severe combined immunodeficiency (SCID mice), i.e., mice in which the differentiation of both T and B lymphocytes is severely impaired, was studied. All control (infected and not treated with antibodies or with immune spleen cells) SCID mice were dead by 17 days after intracutaneous injection in the right midflank with 1 x 10(5) PFU of a virulent HSV-1 strain, Hayashida. Immunization with an avirulent strain of HSV-1 (SKa) did not protect them from death or prolong the survival time. Tissue virus titration of infected mice killed at various times after inoculation detected infectious virus in various organs, dorsal root ganglia, spinal cord, brain, kidney and adrenal gland in addition to the inoculation site of the skin in SCID mice, whereas virus could be detected only in the inoculation site and the nervous tissues in euthymic BALB/c mice, and in the adrenal gland from only one out of 17 nude mice. Human gamma globulin containing neutralizing antibody against HSV-1 prolonged the survival time but did not protect SCID mice from death. Transfer of spleen cells from immunized BALB/c mice protected the infected SCID mice from death. Treatment of spleen cells with anti-Thy 1.2 monoclonal antibody and complement abolished the protection.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Minagawa H,Sakuma S,Mohri S,Mori R,Watanabe Tdoi
10.1007/BF01319810subject
Has Abstractpub_date
1988-01-01 00:00:00pages
73-82issue
1-2eissn
0304-8608issn
1432-8798journal_volume
103pub_type
杂志文章abstract：:Coxsackievirus B (CVB) can cause aseptic meningitis, myocarditis and respiratory disease, especially in newborn infants. To compare the susceptibility to CVB infection of fetal and adult mice, we prepared primary alveolar epithelial cells (AECs) from lungs of BALB/c mice. In contrast to fetal mouse AECs, those of adul...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1254-6
更新日期：2012-06-01 00:00:00
abstract：:The genomic RNA of infectious flacherie virus (IFV), an insect picornavirus, was shown to contain a covalently attached substance which can be labeled with 125I-Bolton and Hunter reagent. This substance was found to be a protein covalently linked to the virus genome, because it cosedimented and was copurified with the...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317378
更新日期：1986-01-01 00:00:00
abstract：:Sequence analysis of a 6.4 kb DNA region from the Spodoptera littoralis multinucleocapsid nucleopolyhedrovirus (SpliNPV) revealed a large open reading frame (ORF) encoding a predicted polypeptide of 998 amino acid (aa) residues with a molecular mass of 114.93 kDa, located between 47.2-52.3 m.u. on the SpliNPV genome. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050170177
更新日期：2001-01-01 00:00:00
abstract：:Trigeminal ganglia from swine latently infected with pseudorabies virus (PRV) were examined for the presence of PRV nucleic acids by in situ hybridization. Both viral DNA and RNA were detectable in latently infected neurons, indicating that the PRV genome is transcriptionally active during the latent phase of infectio...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01321010
更新日期：1988-01-01 00:00:00
abstract：:To elucidate changes associated with the attenuated virulence in a modified live porcine reproductive and respiratory syndrome (PRRS) vaccine (Boehringer Ingelheim Animal Health, St. Joseph, MO), derived from an American prototype ATCC virus VR-2332, nucleotide sequence of 3' genome covering open reading frames (ORFs)...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050316
更新日期：1998-01-01 00:00:00
abstract：:Five cDNA probes prepared from molecular clones representing genomic RNA sequences of the virulent Miller strain of transmissible gastroenteritis virus (TGEV) were used in a dot blot hybridization assay to detect TGEV in cell culture and fecal specimens. Two clones (pA2 and pB4) represent nucleotide base pairs at the ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01319234
更新日期：1991-01-01 00:00:00
abstract：:The temperature sensitivity of herpes simplex virus type 1 (HSV-1) was assessed in primary cultures of mouse central nervous system (MNS) cells and mouse embryo cells (MEC). Infectious yields were determined and the ultrastructural morphogenesis of HSV-1 particles was compared following incubation at 37 or 40.5 degree...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01309574
更新日期：1992-01-01 00:00:00
abstract：:The plaque size and morphology of twenty-two influenza A virus recombinants representing seven distinct families were analyzed on MDCK cells. By examination of the genetic composition of the recombinants no relationship could be established between any gene, including those coding for the surface antigens, and the pla...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314716
更新日期：1982-01-01 00:00:00
abstract：:In this study, a novel filamentous phage, φSHP1, of the environmental Stenotrophomonas maltophilia strain P2 was isolated and characterized. Electron microscopy showed that φSHP1 resembled members of the family Inoviridae and was about 2.1 μm long. The 6,867-nucleotide genome of φSHP1 was a circular single-stranded DN...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1305-z
更新日期：2012-09-01 00:00:00
abstract：:Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) polyhedrin gene from natural mutant strain B, B2 and P was cloned and the amino acid sequence was compared with that of wild-type virus (strain H). Chimeric polyhedrin genes (8 types) containing only one site of mutation within the amino acid sequence were also constr...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050283
更新日期：1998-01-01 00:00:00
abstract：:Poliovirus induces bcl-2-independent apoptosis in the human U937 promonocytic cell line [28]. Here we describe that this cell death, induced after viral infection, correlates with the modulation of the protooncoprotein Bcl-xl. Furthermore, poliovirus infection decreases the detected Bcl-xl in a U937 clone that overexp...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-002-0881-8
更新日期：2002-12-01 00:00:00
abstract：:Among the four flavonoids tested quercetin and morin proved to be significantly effective against lethal Mengo virus-induced encephalitis in mice when the drugs were adminsitered orally (p.o.). With subcutaneous (s.c.) administration all four drugs failed to prevent mortality in the infected mice. Quercetin produced m...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01315089
更新日期：1978-01-01 00:00:00
abstract：:Measles surveillance and epidemiological investigation are beneficial tools for genetic analysis and documentation of the interruption of transmission of endemic measles. In this study, areas of Uttar Pradesh, India, associated with measles outbreaks were investigated. Random blood and urine samples were collected fro...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1227-9
更新日期：2012-04-01 00:00:00
abstract：:Monensin, at concentrations which depended on the multiplicity of infection, was found to prevent DNA replication of human cytomegalovirus (HCMV) as well as production of viral progeny in human foreskin fibroblasts. The drug did not affect DNA replication of herpes simplex virus. Inhibition of consecutive HCMV DNA syn...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310716
更新日期：1987-01-01 00:00:00
abstract：:Samples containing two viruses belonging to the genus Polerovirus, beet chlorosis virus (BChV) and beet mild yellowing virus (BMYV), were collected from French and Polish sugar beet fields. The molecular properties of 24 isolates of BChV and BMYV were investigated, and their genetic diversity was examined in the coat ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2245-6
更新日期：2015-02-01 00:00:00
abstract：:Eco RI fragment G of equine herpesvirus 4 strain 405/76 (EHV 4.405/76) is located at the left end of the unique short region close to or extending into the internal repeat region of the prototypic arrangement of the genome. The nucleotide sequence of two subclones designated HS and G 19, contiguous within Eco RI fragm...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01309795
更新日期：1993-01-01 00:00:00
abstract：:BHK monolayer and suspension cell populations maintained in different laboratories were found to vary in their susceptibility to infection with three strains of foot-and-mouth disease virus (FMDV). The susceptibility of parent cell populations was compared with that of individual clones of cells derived from them. The...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01320756
更新日期：1980-01-01 00:00:00
abstract：:Murine flank scarification with HSV-1 and -2 results in primary lesions at the site of inoculation within three days and lesions at secondary sites within four days. The severity of the infection can be given a numerical value or "score" which is derived from the number and size of these lesions. Using this model, we ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050030
更新日期：2000-01-01 00:00:00
abstract：:Rice black-streaked dwarf virus (RBSDV) is an economically important virus that causes maize rough dwarf disease and rice black-streaked dwarf disease in East Asia. To study RBSDV variation and recombination, we examined the segment 9 (S9) sequences of 49 RBSDV isolates from maize and rice in China. Three S9 recombina...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2291-0
更新日期：2015-04-01 00:00:00
abstract：:Viral infections of the central nervous system (CNS) following peripheral inoculation of Sindbis viruses were studied. The use of viral strains, which vary in their neuroinvasive and neurovirulent properties, and various strains of mice, which differ in immunocompetence, revealed several pathways of viral neuroinvasio...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050576
更新日期：1999-01-01 00:00:00
abstract：:Chilo iridescent virus (CIV) belongs to the family Iridoviridae, which are icosahedral cytoplasmic DNA viruses with large, linear, and circularly permuted genomes. Previous studies on infected-cell-specific polypeptides suggested temporal regulation of CIV gene expression. Recently, we demonstrated three temporal clas...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-003-0232-4
更新日期：2004-04-01 00:00:00
abstract：:Genetic relationships among echovirus type 25 (ECV 25) isolates associated with aseptic meningitis in Germany 1997/98 and a 40-year-old ECV 25 prototype strain were investigated using RT-PCR and direct sequencing the VP1/2A gene junction region. Sequences were compared to each other and to non-polio enterovirus repres...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050640
更新日期：1999-01-01 00:00:00
abstract：:A virus isolated from sorghum in Nigeria has been partially characterized. It was tested by enzyme-linked immunosorbent assay (ELISA) using antisera to Maize dwarf mosaic virus, Johnsongrass mosaic virus (JGMV), Sugarcane mosaic virus strain-MDB, Sorghum mosaic virus, and Zea mosaic virus. A partial host range, sympto...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-004-0411-y
更新日期：2005-03-01 00:00:00
abstract：:Eighty-six varicella-zoster virus (VZV) strains of clades 1, 3 and 5, isolated from varicella and zoster patients in Germany, were analyzed by sequencing the glycoprotein E gene. Four novel non-synonymous and 10 novel synonymous mutations were detected. Of these, two synonymous (C513T, C885T) and two non-synonymous mu...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-010-0864-0
更新日期：2011-03-01 00:00:00
abstract：:Hepatitis E is rare in Japan but is occurring more frequently than previously thought. To investigate whether de novo subclinical infection of hepatitis E virus (HEV) has recently increased in Japan, HEV RNA was assayed in serum samples obtained from 4019 Japanese voluntary blood donors with alanine aminotransferase (...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-007-0996-z
更新日期：2007-01-01 00:00:00
abstract：:Recently, a novel reassortant virus, influenza A(H3N2)v [A(H3N2)v], was identified as the causative pathogen in 307 human cases of influenza in the United States. A(H3N2)v contains the matrix gene from the 2009 pandemic H1N1 (pH1N1) virus, while its other genes originate from H3N2 viruses with triple-reassorted intern...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1571-9
更新日期：2013-11-01 00:00:00
abstract：:An electron microsopic study of cell cultures and bovine foetal tracheal organ cultures infected with infectious bovine rhinotracheitis (IBR) virus showed the following. a) The difference in the site at which the outer envelope is acquired in the infected cell is responsible for some morphological differences between ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317842
更新日期：1976-01-01 00:00:00
abstract：:We have sequenced the genome of a novel picornavirus, rabovirus A (rat-borne virus, RaBoV-A, NC_026314), which was present in the feces of a Norway rat (Rattus norvegicus) from Berlin, Germany. This virus is related to members of the genera Enterovirus and Sapelovirus. RaboV-A contains a type II IRES that is unlike th...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2523-y
更新日期：2015-10-01 00:00:00
abstract：:Adenoviruses are common pathogens that are responsible for a wide variety of infectious syndromes. The objectives of this study were to identify and characterize members of different adenovirus species at the molecular level and to describe the correlation between viruses and clinical syndromes during a period of 4 ye...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-009-0338-4
更新日期：2009-01-01 00:00:00
abstract：:The RNA binding properties of the prunus necrotic ringspot virus (PNRSV) coat protein (CP) were demonstrated by northwestern and dot-blot analyses. The capability to bind PNRSV RNA 4 was compared with viruses representing three different interactions prevailing in the assembly and architecture of virions. The results ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050545
更新日期：1999-01-01 00:00:00
