Effectiveness of first-line antiretroviral therapy in HIV/AIDS patients: A 5-year longitudinal evaluation in Fujian Province, Southeast China.


:The aim of this study was to evaluate the long-term effectiveness of first-line antiretroviral therapy in HIV/AIDS patients in Southeast China. A total of 450 eligible patients were selected to initiate first-line antiretroviral therapy from February 2005 through August 2009. During the study period from 2009 through 2013, each subject received clinical and laboratory monitoring for effectiveness, safety and toxicity once every 3 months in the first year, and once every 6 months in the following years. The response to first-line antiretroviral therapy was evaluated through body weight gain and immunological and virological outcomes. During the mean follow-up period of 70.86 ± 28.9 months, the overall mortality was 14.2%. The mean body weight and CD4(+) counts increased significantly following antiretroviral therapy as compared to baselines across the follow-up period, and the rate of immunological effectiveness was over 85% in all subjects at 2 to 5 years of treatment. The rate of inhibition of HIV virus was 87.67%, 89.32%, 91.73%, 92.8% and 91.63% across the study period. In addition, significant differences were detected after treatment as compared to baselines, and Pearson correlation analysis revealed a positive correlation between immunological effectiveness and viral inhibition. Forty-eight percent of the subjects changed antiretroviral drugs once, and 16.22% twice, and 31 patients switched from first-line to second-line antiretroviral therapy. Long-term antiretroviral therapy remains effective for treatment of HIV/AIDS, resulting in higher mean body weight, effective viral inhibition and a higher CD4 count. Immunological effectiveness of antiretroviral therapy positively correlates with HIV viral inhibition.


Arch Virol


Archives of virology


Wu S,Qiu Y,Yan P,Wang W,Xie M,Xia P,Wang Z,Yan Y




Has Abstract


2015-11-01 00:00:00














  • Genetic variability of the coat protein sequence of pea seed-borne mosaic virus isolates and the current relationship between phylogenetic placement and resistance groups.

    abstract::Nucleotide sequences of complete or partial coat protein (CP) genes were determined for 11 isolates of pea seed-borne mosaic virus (PSbMV) from Australia and one from China, and compared with known sequences of 20 other isolates. On phylogenetic analysis, the isolates from Australia and China grouped into 2 of 3 clade...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Wylie SJ,Coutts BA,Jones RA

    更新日期:2011-07-01 00:00:00

  • Hepatitis C virus infection in mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma: evidence for a pathogenetic role.

    abstract::We investigated the pathogenetic relevance of hepatitis C virus (HCV) infection in mixed cryoglobulinemia (MC) with or without complicating B-cell Non-Hodgkin's lymphoma (NHL) in comparison with other immunological and lymphoproliferative disorders. The following groups of patients were studied: A) 25 patients with MC...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Zignego AL,Ferri C,Giannini C,La Civita L,Careccia G,Longombardo G,Bellesi G,Caracciolo F,Thiers V,Gentilini P

    更新日期:1997-01-01 00:00:00

  • First detection of wheat streak mosaic virus in Germany: molecular and biological characteristics.

    abstract::Wheat streak mosaic virus is a serious threat in wheat-producing countries. In Germany, the virus was first recorded in 2013 near Hoym. The complete sequence of isolate Hoym was obtained and compared to all other known complete WSMV sequences, including newly collected and sequenced isolates from France and Austria. P...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Schubert J,Ziegler A,Rabenstein F

    更新日期:2015-07-01 00:00:00

  • Tetracycline and viruses: a possible treatment for COVID-19?

    abstract::Tetracyclines have been used to treat many bacterial infections. The use of these antibiotics for the treatment of viral diseases dates to the 1960s to 1970s. Over the decades, the effect of tetracyclines on the pathogenesis of viral infections has been demonstrated both clinically and experimentally. Tetracyclines ca...

    journal_title:Archives of virology

    pub_type: 杂志文章,评审


    authors: Mosquera-Sulbaran JA,Hernández-Fonseca H

    更新日期:2021-01-01 00:00:00

  • Complete genome analysis of Pantoea agglomerans-infecting bacteriophage vB_PagM_AAM22.

    abstract::A novel myovirus, vB_PagM_AAM22 (AAM22), was isolated in Lithuania using Pantoea agglomerans as the host for phage propagation. The 49,744-bp genome of AAM22 has a G + C content of 48.4% and contains 96 probable protein-encoding genes and no genes for tRNA. In total, 34 ORFs were given a putative functional annotation...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Truncaitė L,Šimoliūnienė M,Alijošius L,Petrauskaitė E,Kiaušaitė L,Meškys R,Skapas M,Šimoliūnas E

    更新日期:2020-09-01 00:00:00

  • Generation and characterization of the human immunodeficiency virus type 1 mutants.

    abstract::Mutations were introduced by recombinant DNA techniques into 9 genes of an infectious molecular clone of human immunodeficiency virus type 1. The 24 mutants generated were characterized biochemically and biologically by transfection and infection experiments. None of the mutants which have mutations in gag (p17, p24, ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Adachi A,Ono N,Sakai H,Ogawa K,Shibata R,Kiyomasu T,Masuike H,Ueda S

    更新日期:1991-01-01 00:00:00

  • Restriction fragment pattern analysis of genomes from French isolates of suis herpes virus 1 (Aujeszky's disease virus).

    abstract::Purified DNA from 45 isolates of suis herpes virus 1 (SHV1) collected between 1980 and 1987 from clinical outbreaks of Aujeszky's disease on French farms was compared by restriction fragment pattern (RFP) analysis. The BamHI generated RFPs were found to be distinguishable, confirming RFP analysis as a potential epidem...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Jestin A,Blanchard P,Garbar-Chenon A,Vannier P,Nicolas JC

    更新日期:1990-01-01 00:00:00

  • Absence of neuraminidase from influenza C virus.

    abstract::Influenza C viruses did not possess neuraminidase activity when examined using either fetuin or sialyllactose as substrate. Purified preparations of influenza C virus inhibited hemagglutination by NWS hemagglutinin. The hemagglutination inhibiting activity was abolished by treatment of influenza C virus with neuramini...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Nerome K,Ishida M,Nakayama M

    更新日期:1976-01-01 00:00:00

  • Characterisation of novel linear antigen epitopes on North American-type porcine reproductive and respiratory syndrome virus M protein.

    abstract::The M protein, encoded by the porcine reproductive and respiratory syndrome virus (PRRSV) ORF6 gene, is considered to be one of the most conserved PRRSV proteins. In recent decades, highly specific monoclonal antibodies (Mabs) have been exploited to provide reliable diagnoses for many diseases. In this study, two diff...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Wang Q,Chen J,Peng J,An T,Leng C,Sun Y,Guo X,Ge X,Tian Z,Yang H

    更新日期:2014-11-01 00:00:00

  • Genetic and phylogenetic analysis of a new porcine circovirus type 2 (PCV2) strain in China.

    abstract::Porcine circovirus type 2 (PCV2) is the etiological agent associated with several pig diseases that are collectively referred to as porcine circovirus-associated disease (PCVAD). Unfortunately, PCV2 has had a serious economic impact on the swine industry. In this study, we report the genome sequence of a novel PCV2 is...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Zhang D,He K,Wen L,Fan H

    更新日期:2015-12-01 00:00:00

  • A comparative phylogenomic analysis of avian avulavirus 1 isolated from non-avian hosts: conquering new frontiers of zoonotic potential among species.

    abstract::A number of avian avulavirus 1 (AAvV 1) isolates have been reported from avian and non-avian hosts worldwide with varying clinical consequences. In this regard, robust surveillance coupled with advanced diagnostics, genomic analysis, and disease modelling has provided insight into the molecular epidemiology and evolut...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Ul-Rahman A,Shabbir MZ

    更新日期:2019-07-01 00:00:00

  • Complete nucleotide sequence of the genomic RNA of a Japanese yam mosaic virus, a new potyvirus in Japan.

    abstract::We determined the complete nucleotide sequence of a potyvirus purified from a Japanese yam plant. The genomic RNA of this virus is 9,757 nucleotides (nts) in length, excluding the 3'-terminal poly(A) tail. It contains a single open reading frame (ORF) encoding a polyprotein of 3130 amino acids (aa) with a calculated M...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Fuji S,Nakamae H

    更新日期:1999-01-01 00:00:00

  • Characterization of a soybean mosaic virus variant causing different diseases in Glycine max and Nicotiana benthamiana.

    abstract::We discovered a soybean mosaic virus (SMV) variant (4278-1) that caused systemic infections in Nicotiana benthamiana plants, resulting in stem stunting and leaf shriveling. The virus had a particle morphology and incubation period similar to those of other SMV isolates but differed from them in the leaf symptoms it ca...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Jiang H,Li K,Dou D,Gai J

    更新日期:2017-02-01 00:00:00

  • Cloning and sequencing of Duck circovirus (DuCV).

    abstract::The genome of Duck circovirus (DuCV) is circular and 1996 nts in size. Two major open reading frames were identified, encoding the replicase (V1) and the capsid protein (C1). A stem-loop structure comprising the nonamer 5'-TATTATTAC, conserved in all circo-, nano- and geminiviruses, was found. Unique to DuCV, the regi...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Hattermann K,Schmitt C,Soike D,Mankertz A

    更新日期:2003-12-01 00:00:00

  • Perpetuation of influenza A viruses in Alaskan waterfowl reservoirs.

    abstract::To provide information on the mechanism of perpetuation of influenza viruses among waterfowl reservoirs in nature, virological surveillance was carried out in Alaska during their breeding season in summer from 1991 to 1994. Influenza viruses were isolated mainly from fecal samples of dabbling ducks in their nesting pl...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Ito T,Okazaki K,Kawaoka Y,Takada A,Webster RG,Kida H

    更新日期:1995-01-01 00:00:00

  • Detection of hepatitis E virus in slaughtered pigs in Italy.

    abstract::The stools of slaughtered pigs were screened for hepatitis E virus (HEV). HEV RNA was detected in 7.3% of the samples. HEV strains were characterized as genotype 3 subtype c, a cluster previously not described in Italy. These findings provide evidence that slaughterhouse workers may be exposed to HEV infection. ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Di Martino B,Di Profio F,Martella V,Di Felice E,Di Francesco CE,Ceci C,Marsilio F

    更新日期:2010-01-01 00:00:00

  • Lamium amplexicaule (Lamiaceae): a weed reservoir for tomato yellow leaf curl virus (TYLCV) in Korea.

    abstract::After the first identification of tomato yellow leaf curl virus (TYLCV) in the southern part of Korea in 2008, TYLCV has rapidly spread to tomato farms in most regions of Korea. From 2008 to 2010, a survey of natural weed hosts that could be reservoirs of TYLCV was performed in major tomato production areas of Korea. ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Kil EJ,Park J,Lee H,Kim J,Choi HS,Lee KY,Kim CS,Lee S

    更新日期:2014-06-01 00:00:00

  • Genetic characterization of influenza A virus subtype H12N1 isolated from a watercock and lesser whistling ducks in Thailand.

    abstract::Monitoring of influenza A virus (IAV) was conducted in wild bird species in central Thailand. Four IAV subtype H12N1 strains were isolated from a watercock (order Gruiformes, family Rallidae) (n = 1) and lesser whistling ducks (order Anseriformes, family Anatidae) (n = 3). All H12N1 viruses were characterized by whole...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Wongphatcharachai M,Wisedchanwet T,Lapkuntod J,Nonthabenjawan N,Jairak W,Amonsin A

    更新日期:2012-06-01 00:00:00

  • Prevalence of equine herpesvirus type 1 latency detected by polymerase chain reaction.

    abstract::In this study, an improved polymerase chain reaction (PCR) was used for detection of DNA of latent EHV-1 strains from several sources. Three pairs of oligonucleotide primers spanning fragments of 333 bp, 226 bp and 268 bp of the thymidine kinase (tk) gene, and one primer pair spanning 225 bp of the glycoprotein C (gC)...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Carvalho R,Oliveira AM,Souza AM,Passos LM,Martins AS

    更新日期:2000-01-01 00:00:00

  • Protective efficacy in mice of a secreted form of recombinant dengue-2 virus envelope protein produced in baculovirus infected insect cells.

    abstract::We constructed a recombinant baculovirus encoding a dengue (DEN)-2 virus envelope glycoprotein truncated of 102 amino acids (aa) at its C-terminus (D2E delta 102). The production, processing and transportation of the recombinant protein in baculovirus-infected Spodoptera frugiperda (Sf9) cells and its immunogenic prop...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Delenda C,Frenkiel MP,Deubel V

    更新日期:1994-01-01 00:00:00

  • Nucleotide sequences of the helper component-proteinase genes of aphid transmissible and non-transmissible isolates of turnip mosaic virus.

    abstract::We have compared nucleotide sequences of the helper component-proteinase (HC-Pro) coding region of aphid transmissible (isolate 1) and non-transmissible (isolate 31) isolates of turnip mosaic virus (TuMV). HC-Pro coding regions of both TuMV isolates 1 and 31 were 1,374 nucleotide long. The nucleotide sequence homology...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Nakashima H,Sako N,Hori K

    更新日期:1993-01-01 00:00:00

  • Quantitative analysis of the Epstein-Barr virus-inducing properties of short-chain fatty acids present in the culture fluids of oral bacteria.

    abstract::The culture fluids of various anaerobic bacteria induced the synthesis of early antigens (EA) in Epstein-Barr virus (EBV) carrying lymphoblastoid cells. The culture fluids of Corynebacterium butyricum and Fusobacterium nucleatum were the effective inducer on EA. The inducing activity was, to some extent, dependent on ...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Asai S,Nakamura Y,Yamamura M,Ikezawa H,Namikawa I

    更新日期:1991-01-01 00:00:00

  • Abortive infection of influenza virus in Ehrlich ascites tumor cells. Unusual fragility of virus particles.

    abstract::Noninfectious virus particles were produced in Ehrlich ascites tumor cells infected intraperitoneally with fowl plague virus. The PFU yield of virus per cell was less than 0.1 and the ratio PFU/HA units in the progeny virus was less than 10(3). The virus particles had the same morphology and size as egg-grown virus bu...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Bukrinskaya AG,Gitelman AK,Martynenko VB

    更新日期:1978-01-01 00:00:00

  • Genetic polymorphism across regions of the three open reading frames of "Norwalk-like viruses".

    abstract::Genomic characterization of Norwalk-like human caliciviruses (NLVs) originating from outbreaks and sporadic cases of acute gastroenteritis has revealed surprisingly high levels of diversity, even in the RNA polymerase gene, which is anticipated to be highly conserved. Since information on antigenic relationship is lim...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Vinjé J,Green J,Lewis DC,Gallimore CI,Brown DW,Koopmans MP

    更新日期:2000-01-01 00:00:00

  • Bovine herpesvirus type 1 gp87 mediates both attachment of virions to susceptible cells and hemagglutination.

    abstract::The 87,000-dalton glycoprotein (gp87) of bovine herpesvirus type 1 (BHV-1) was found to selectively attach to susceptible cells. The attachment of gp87 to the cells was markedly decreased by the prior adsorption of intact virions. Anti-gp87 (site Ia) monoclonal antibody, which inhibited BHV-1 adsorption to the cells a...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Okazaki K,Honda E,Minetoma T,Kumagai T

    更新日期:1987-01-01 00:00:00

  • Molecular characterization of HLJ-073, a recombinant canine coronavirus strain from China with an ORF3abc deletion.

    abstract::Canine enteric coronaviruses (CCoVs) are important enteric pathogens of dogs. CCoVs with different variations are typically pantropic and pathogenic in dogs. In this study, we isolated a CCoV, designated HLJ-073, from a dead 6-week-old male Pekingese with gross lesions and diarrhea. Interestingly, sequence analysis su...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Chen S,Liu D,Tian J,Kang H,Guo D,Jiang Q,Liu J,Li Z,Hu X,Qu L

    更新日期:2019-08-01 00:00:00

  • Identification of three N-linked glycans in the V4-V5 region of HIV-1 gp 120, dispensable for CD4-binding and fusion activity of gp 120.

    abstract::Site-directed mutagenesis was used to study the biological significance of three N-linked glycans (linked to Asn406, Asn448, and Asn463), situated in the CD4-binding region of gp120. Mutagenesis was carried out in a phage M13 system, and the mutated env genes were inserted into recombinant vaccinia virus (r-vaccinia v...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Hemming A,Bolmstedt A,Jansson B,Hansen JE,Travis B,Hu SL,Olofsson S

    更新日期:1994-01-01 00:00:00

  • Genome sequence of bubaline alphaherpesvirus 1 (BuHV1) isolated in Australia in 1972.

    abstract::Bubaline alphaherpesvirus 1 (BuHV1) is a member of the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus. To date, no full genome sequence of BuHV has been published. Here, we report the complete genome sequence of bubaline alphaherpesvirus 1 (BuHV1) strain b6 (BuHV1-b6), isolated from a water b...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Scheffer CM,Varela AP,Cibulski SP,Schmidt C,Campos FS,Paim WP,Dos Santos RN,Teixeira TF,Loiko MR,Tochetto C,Dos Santos HF,de Lima DA,Cerva C,Mayer FQ,Petzhold SA,Franco AC,George TS,Spilki FR,Roehe PM

    更新日期:2017-05-01 00:00:00

  • Genetic evolution of equine influenza viruses isolated in China.

    abstract::China experienced an outbreak of equine influenza during 2007-2008. Meanwhile, its neighbor countries, such as Mongolia, India and Japan, have also been affected by various influenza virus strains in each country. Phylogenetic analysis showed that the newly emerging Chinese strains belong to Florida sublineage clade 2...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Qi T,Guo W,Huang WQ,Li HM,Zhao LP,Dai LL,He N,Hao XF,Xiang WH

    更新日期:2010-09-01 00:00:00

  • The complete nucleotide sequence of turnip mosaic virus RNA Japanese strain.

    abstract::The complete nucleotide sequence of the RNA genome of turnip mosaic virus Japanese strain (TuMV-J) has been determined from five overlapping cDNA clones and by direct sequencing of viral RNA. The RNA sequence was 9833 nucleotides in length, excluding a 3' terminal poly(A) tail. An AUG triplet at position 130-132 was a...

    journal_title:Archives of virology

    pub_type: 杂志文章


    authors: Ohshima K,Tanaka M,Sako N

    更新日期:1996-01-01 00:00:00