HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing.

Abstract:

:The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Chatterjee S,Wang JW,Cismowski MJ,Bower JR,Rosenthal KS

doi

10.1007/s00705-009-0341-9

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

661-3

issue

4

eissn

0304-8608

issn

1432-8798

journal_volume

154

pub_type

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