Inhibition of interferon production and antiviral action in mouse cells by 4,5',8-trimethylpsoralen activated with near ultraviolet light. Brief report.

Abstract:

:The DNA of mammalian cells treated with 4,5',8-trimethylpsoralen (Trioxsalen) is crosslinked (preventing transcription) only after photoactivation with near ultraviolet light. Suppression of gene action in cocultivated or fused cultures, including both induction and antiviral action of fibroblast interferon, can consequently be limited to pretreated cells, an advantage over actinomycin treatment.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Sakaguchi AY,Stevenson D,Gordon I

doi

10.1007/BF01320762

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

69-74

issue

1

eissn

0304-8608

issn

1432-8798

journal_volume

63

pub_type

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