Experimental parainfluenza virus infection in mice: growth and spread of a highly pathogenic variant of parainfluenza 3 virus in the mouse brain.

Abstract:

:We had previously showed that following intracerebral inoculation of newborn mice, the 910 N and M strains of bovine parainfluenza 3 virus induce a non-lethal hydrocephalus and a lethal disease with marked thymic and splenic atrophy, respectively. Moreover, only the M virus was lethal for 2-week-old mice. In the present study, we demonstrate that the M virus multiplies and spreads in the mouse brain invading the thalamus, hypothalamus and brain stem beyond the ependyma whereas the 910 N virus causes only slight ependymitis. This growth and spread of M virus was blocked by passive immunization 3 days after infection. Mouse embryo brain cell cultures were infected with M and 910 N viruses, about 50 per cent became antigen-positive for M whereas only a small proportion of cells were positive for the 910 N virus. However, the latter did produce higher yeilds of infectious virus than M.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Shibuta H,Kanda T,Nozawa A,Sato S,Kumanishi T

doi

10.1007/BF01310963

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

43-52

issue

1-2

eissn

0304-8608

issn

1432-8798

journal_volume

83

pub_type

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