Conservation of epitopes recognized by monoclonal antibodies against the separated subunits of influenza hemagglutinin among type A viruses of the same and different subtypes.

Abstract:

:Monoclonal antibodies raised against the separated hemagglutinin subunits (HA1 and HA2) of influenza A/Vic/3/75 (H3N2) virus were tested against a large panel of human and avian strains. The epitopes recognized by most antibodies were conserved among subtype H3 viruses, but reactivity of some antibodies with members of other subtypes was also observed. Particularly, the H4 virus reacted with most antibodies directed against the HA2 subunit. These results are discussed in terms of sequence similarities between subtypes and application of these antibodies as subtyping reagents.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Sanchez-Fauquier A,Guillen M,Martin J,Kendal AP,Melero JA

doi

10.1007/BF01319250

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

285-92

issue

1-4

eissn

0304-8608

issn

1432-8798

journal_volume

116

pub_type

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