Combinatory effects of vaccinia virus VG9 and the STAT3 inhibitor Stattic on cancer therapy.

Abstract:

:The recombinant vaccinia virus VG9 and the STAT3 inhibitor Stattic were combined to kill cancer cells via both oncolytic activity and inhibition of STAT3 phosphorylation in cells. The combinatory anti-tumour activity of these compounds was superior to the activity of VG9 or Stattic alone in vivo. The inhibition of tumour growth occurred via increased apoptosis and autophagy pathways. Furthermore, the combinatory anti-tumour activity was more efficient than that of VG9 or Stattic alone on xenografts, especially in nude mice.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Yang R,Wang L,Sheng J,Huang Q,Pan D,Xu Y,Yan J,Wang X,Dong Z,Yang M

doi

10.1007/s00705-019-04257-2

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

1805-1814

issue

7

eissn

0304-8608

issn

1432-8798

pii

10.1007/s00705-019-04257-2

journal_volume

164

pub_type

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