Abstract:
:The recombinant vaccinia virus VG9 and the STAT3 inhibitor Stattic were combined to kill cancer cells via both oncolytic activity and inhibition of STAT3 phosphorylation in cells. The combinatory anti-tumour activity of these compounds was superior to the activity of VG9 or Stattic alone in vivo. The inhibition of tumour growth occurred via increased apoptosis and autophagy pathways. Furthermore, the combinatory anti-tumour activity was more efficient than that of VG9 or Stattic alone on xenografts, especially in nude mice.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Yang R,Wang L,Sheng J,Huang Q,Pan D,Xu Y,Yan J,Wang X,Dong Z,Yang Mdoi
10.1007/s00705-019-04257-2subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1805-1814issue
7eissn
0304-8608issn
1432-8798pii
10.1007/s00705-019-04257-2journal_volume
164pub_type
杂志文章abstract::Cultures from pig bone marrow cells were infected with ASFV and the replication cycle was studied. In the cytoplasmic replication areas there are a differentiation of membrane segments. Some of them are polygonal, which give rise to virus particles. An over production of viral coded materials, including non-polygonal ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF02175596
更新日期:1975-01-01 00:00:00
abstract::H9N2 avian influenza virus has caused huge economic loss for the Chinese poultry industry since it was first identified. Vaccination is frequently used as a control method for the disease. Meanwhile suspension culture has become an important tool for the development of influenza vaccines. To optimize the suspension cu...
journal_title:Archives of virology
pub_type: 临床试验,杂志文章
doi:10.1007/s00705-017-3460-8
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abstract::The full length gene for the coat protein (CP) of the potyvirus, Johnsongrass mosaic virus, was incorporated into recombinant baculovirus and expressed in insect cells. Western blot and Coomassie-stained polyacrylamide gel electrophoresis analysis of infected insect cells demonstrated that CP was produced in large qua...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01321065
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abstract::Infectious laryngotracheitis (ILT), caused by infectious laryngotracheitis virus (ILTV), is an Office International des Epizooties (OIE) notifiable disease. However, we have not clearly understood the dynamic distribution, tissue tropism, pathogenesis, and replication of ILTV in chickens. In this report, we investigat...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-012-1414-8
更新日期:2013-03-01 00:00:00
abstract::The complete genomic sequence of Cassava Ivorian bacilliform virus (CIBV) is described. The virus has a genomic organization similar to that of pelargonium zonate spot virus (PZSV), the type member of the genus Anulavirus, but it is most closely related to a second, recently described, anulavirus, Amazon lily mild mot...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-014-2086-3
更新日期:2014-10-01 00:00:00
abstract::In order to investigate the mechanism of long-term immunity and the effect of protective immunity induced by DNA vaccination, we constructed the expression plasmid containing a pseudorabies virus (PRV) gD gene encoding an envelope glycoprotein. Intramuscular vaccination of mice with the plasmid DNA induced a strong an...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050050272
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abstract::A 945 nucleotide region (bases 76-1020) of the HA1 part of the HA gene was obtained for 31 influenza viruses of H7 subtype isolated primarily from Europe, Asia and Australia over the last 20 years. These were analysed phylogenetically and compared with sequences of the same region from 23 H7 subtype viruses available ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050050695
更新日期:2000-01-01 00:00:00
abstract::A bovine monoclonal antibody specific for bovine viral diarrhoea virus (BVDV) recognized all the reference strains of BVDV and over 90% of the field isolates tested. It neutralized the virus and precipitated a 56 k-58 k viral protein. ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01316756
更新日期:1991-01-01 00:00:00
abstract::Recently, five new viruses from the genus Vitivirus were identified and named grapevine virus G, H, I, J and L. These viruses were targeted in a survey to evaluate their prevalence in different grapevine populations in California. Excluding a single detection of GVJ, other vitiviruses were detected infecting several g...
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doi:10.1007/s00705-019-04355-1
更新日期:2019-10-01 00:00:00
abstract::A real-time PCR assay based on primer-probe energy transfer (PriProET) was developed to detect swine vesicular disease virus (SVDV). Specificity tests of SVDV and heterologous virus showed specific amplification of SVDV strains only. The amplification plot for the closely related Coxsackievirus B5 remained negative. T...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-006-0817-9
更新日期:2006-12-01 00:00:00
abstract::This report presents a molecular characterization of the complete genome of a rare hepatitis C virus (HCV) genotype (GT5a) from India. Sequence homology of full genome revealed that the strain belonged to HCV GT5a. To trace the origin of this virus and to understand its evolutionary pattern, a phylogenetic reconstruct...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-014-2220-2
更新日期:2015-01-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01317505
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journal_title:Archives of virology
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doi:10.1007/s00705-010-0605-4
更新日期:2010-04-01 00:00:00
abstract::Occult HCV infection (OCI) has been described as the presence of hepatitis C virus (HCV) genomic RNA in hepatocytes and/or peripheral blood mononuclear cell (PBMC) specimens and the lack of HCV genomic RNA and anti-HCV antibodies (Abs) in plasma samples. Injection drug users (IDUs) are the most important high-risk gro...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-018-4066-5
更新日期:2019-02-01 00:00:00
abstract::The effects of human alpha-, beta-, or gamma-interferon (IFN) on the replication and production of human T-lymphotrophic virus type-I (HTLV-I) were investigated in a human T-cell line, MT-2. Virus transmission and production estimated by syncytium formation and HTLV-I-associated reverse transcriptase (RT) activity wer...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310623
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abstract::Immunity induced by DNA vaccines containing the hemagglutinin (H) and nucleoprotein (N) genes of wild-type and attenuated canine distemper virus (CDV) was investigated in mink (Mustela vison), a highly susceptible natural host of CDV. All DNA-immunized mink seroconverted, and significant levels of virus-neutralizing (...
journal_title:Archives of virology
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doi:10.1007/s00705-012-1375-y
更新日期:2012-10-01 00:00:00
abstract::Hippeastrum chlorotic ringspot virus (HCRV) is a novel tospovirus that was identified in Yunnan Province, China, in 2013. We have sequenced the HCRV L gene, which is 8909 nt long and encodes the RNA-dependent RNA polymerase (2873 amino acids, 330.8 kDa). The HCRV L protein shared highest similarity (89.4 %) with that ...
journal_title:Archives of virology
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doi:10.1007/s00705-014-2100-9
更新日期:2014-10-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-015-2542-8
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journal_title:Archives of virology
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doi:10.1007/s00705-013-1787-3
更新日期:2014-01-01 00:00:00
abstract::We report the complete genome sequencing of two Escherichia coli T5-related bacteriophages, DT57C and DT571/2, isolated from the same specimen of horse feces. These two isolates share 96% nucleotide sequence identity and can thus be considered representatives of the same novel species within the genus T5likevirus. The...
journal_title:Archives of virology
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doi:10.1007/s00705-003-0184-8
更新日期:2004-02-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01378978
更新日期:1985-01-01 00:00:00
abstract::Beet necrotic yellow vein virus RNA 1 contains a single long ORF corresponding to the theoretical translation product of 237 kDa which contains the information necessary for replication of the viral genome. This ORF contains a putative papain-like proteinase domain which has been localized, on the basis of sequence al...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050050141
更新日期:1997-01-01 00:00:00
abstract::Molecular epidemiology can be used to identify human immunodeficiency virus (HIV) transmission clusters, usually using pol sequence for analysis. In the present study, we explored appropriate parameters to construct a simple network using HIV env and gag sequences instead of pol sequences for constructing a phylogenet...
journal_title:Archives of virology
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更新日期:2017-11-01 00:00:00
abstract::To characterize the role of the humoral immune response on HIV-1 infection of monocytes and macrophages (M phi s) we examined the susceptibility of in vitro cultured monocyte/M phi s to various HIV-1 isolates and the influence of heterologous and particularly autologous anti HIV-1 sera on this infection. Depending on ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01538815
更新日期:1994-01-01 00:00:00
abstract::A full length cDNA copy of the genomic RNA of lettuce mosaic virus (LMV) was constructed under the control of an enhanced CaMV 35S promoter and of the NOS terminator. This construct was found infectious when inoculated to lettuce plants. The intron II of the bean nitrite reductase gene was engineered into the LMV FL c...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050050474
更新日期:1998-01-01 00:00:00
abstract::The '6K1' protein of the Pinellia isolate of Soybean mosaic virus was cloned into a prokaryotic expression vector and a polyclonal antiserum raised to the expressed fusion protein. In immunogold labeling of thin sections of infected leaves of Pinellia ternata, specific labeling occurred at the cell periphery. This mig...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-007-0972-7
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abstract::In an effort to determine whether distinct types of bovine herpesvirus 1 are responsible for causing specific syndromes, the polypeptides and DNA of 93 BHV 1 isolates from the province of Alberta as well as vaccine strains and numerous other Canadian, U.S. and European isolates were analyzed by PAGE and restriction en...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01311201
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abstract::Alfamo- and ilarviruses are characterized by the deficiency of their genomes (three messenger-sense RNAs) to start an infection cycle. The RNAs are in capsids built from a single species of protein of about 24 kD. A few dimers of this coat protein per RNA molecule are sufficient to activate the genome. Since the first...
journal_title:Archives of virology
pub_type: 杂志文章,评审
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abstract::Foot-and-mouth disease virus (FMDV) causes a highly contagious viral disease of cloven-hoofed animals, which has a considerable socio-economic impact on the countries affected. In addition, persistent infection can occur following clinical or sub-clinical disease in either vaccinated or non-vaccinated cattle. The mech...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-002-0867-6
更新日期:2002-11-01 00:00:00