Antiretroviral drug resistance mutations in the reverse transcriptase gene of HIV-1 isolates from Northern Indian patients: a follow-up study.

Abstract:

:The viral reverse transcriptase gene was amplified from the plasma of 27 drug-naïve and five drug-experienced HIV patients in Northern India. Follow-up samples of naïve patients after antiretroviral therapy initiation were collected in six patients at 3 months and three patients at 6 months. Phylogenetic analysis revealed two new recombinant forms, CRF_CH and CRF_CK, and an accessory non-nucleoside reverse transcriptase inhibitor mutation E138A, not previously reported from India. The major DRMs found in two 6-month follow-up samples were absent in their baseline blood samples. This is the first follow-up study to determine anti-retroviral drug resistance mutations in Indian HIV patients.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Dutta Choudhury S,Chaudhury AK,Kalra R,Andrabi R,Wig N,Biswas A,Bala M,Luthra K

doi

10.1007/s00705-010-0605-4

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

563-9

issue

4

eissn

0304-8608

issn

1432-8798

journal_volume

155

pub_type

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