Abstract:
:The viral reverse transcriptase gene was amplified from the plasma of 27 drug-naïve and five drug-experienced HIV patients in Northern India. Follow-up samples of naïve patients after antiretroviral therapy initiation were collected in six patients at 3 months and three patients at 6 months. Phylogenetic analysis revealed two new recombinant forms, CRF_CH and CRF_CK, and an accessory non-nucleoside reverse transcriptase inhibitor mutation E138A, not previously reported from India. The major DRMs found in two 6-month follow-up samples were absent in their baseline blood samples. This is the first follow-up study to determine anti-retroviral drug resistance mutations in Indian HIV patients.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Dutta Choudhury S,Chaudhury AK,Kalra R,Andrabi R,Wig N,Biswas A,Bala M,Luthra Kdoi
10.1007/s00705-010-0605-4subject
Has Abstractpub_date
2010-04-01 00:00:00pages
563-9issue
4eissn
0304-8608issn
1432-8798journal_volume
155pub_type
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