Expression, cellular localization and antibody responses of the African swine fever virus genes B602L and K205R.

Abstract:

:Previously, we identified serological immunodeterminants of African swine fever virus (ASFV), including pK205R and pB602L, without homologues in the database. pK205R is expressed as a 33-kD protein from 4 h post-infection onward, initially diffusely distributed throughout cells, and subsequently in viral factories. pK205R was not found in purified virus. Both pK205R and pB602L are recognised by hyperimmune antisera from domestic pigs and bushpigs at late time points after infection, suggesting they may be useful diagnostically to distinguish animals persistently infected with virus.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Gutiérrez-Castañeda B,Reis AL,Corteyn A,Parkhouse RM,Kollnberger S

doi

10.1007/s00705-008-0246-z

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

2303-6

issue

12

eissn

0304-8608

issn

1432-8798

journal_volume

153

pub_type

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