Abstract:
:Immunity induced by DNA vaccines containing the hemagglutinin (H) and nucleoprotein (N) genes of wild-type and attenuated canine distemper virus (CDV) was investigated in mink (Mustela vison), a highly susceptible natural host of CDV. All DNA-immunized mink seroconverted, and significant levels of virus-neutralizing (VN) antibodies were present on the day of challenge with wild-type CDV. The DNA vaccines also primed the cell-mediated memory responses, as indicated by an early increase in the number of interferon-gamma (IFN-γ)-producing lymphocytes after challenge. Importantly, the wild-type and attenuated CDV DNA vaccines had a long-term protective effect against wild-type CDV challenge. The vaccine-induced immunity induced by the H and N genes from wild-type CDV and those from attenuated CDV was comparable. Because these two DNA vaccines were shown to protect equally well against wild-type virus challenge, it is suggested that the genetic/antigenic heterogeneity between vaccine strains and contemporary wild-type strains are unlikely to cause vaccine failure.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Nielsen L,Jensen TH,Kristensen B,Jensen TD,Karlskov-Mortensen P,Lund M,Aasted B,Blixenkrone-Møller Mdoi
10.1007/s00705-012-1375-ysubject
Has Abstractpub_date
2012-10-01 00:00:00pages
1887-96issue
10eissn
0304-8608issn
1432-8798journal_volume
157pub_type
杂志文章abstract::We determined the complete genome sequence of a South Korean (SK) isolate of Brugmansia mosaic virus (BruMV), which has recently been proposed to be a member of a new species in the genus Potyvirus. The genomic RNA of BruMV isolate SK is 9781 nucleotides in length (excluding the 3'-terminal poly (A)) and shares comple...
journal_title:Archives of virology
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doi:10.1007/s00705-013-1693-8
更新日期:2013-09-01 00:00:00
abstract::Translation of poliovirus RNA is initiated by entry of ribosomes into the nucleotide sequence (internal ribosomal entry site; IRES) within the 5'-untranslated region (5'-UTR). Efficiency of this translation initiation in rabbit reticulocyte lysates (RRL) was very low and was greatly enhanced by addition of the ribosom...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310034
更新日期:1994-01-01 00:00:00
abstract::Site-directed mutagenesis was used to study the biological significance of three N-linked glycans (linked to Asn406, Asn448, and Asn463), situated in the CD4-binding region of gp120. Mutagenesis was carried out in a phage M13 system, and the mutated env genes were inserted into recombinant vaccinia virus (r-vaccinia v...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310571
更新日期:1994-01-01 00:00:00
abstract::PCR products representing c. 550 3' terminal bases of Beet soil-borne pomovirus (BSBV) RNA 3 were compared for sources of this virus from all major sugarbeet-growing areas in Germany. In none of these areas conspicious symptoms could be attributed to the presence of BSBV. Single strand conformation polymorphism analys...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050070117
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abstract::We investigated the pathogenetic relevance of hepatitis C virus (HCV) infection in mixed cryoglobulinemia (MC) with or without complicating B-cell Non-Hodgkin's lymphoma (NHL) in comparison with other immunological and lymphoproliferative disorders. The following groups of patients were studied: A) 25 patients with MC...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050050100
更新日期:1997-01-01 00:00:00
abstract::Synthetic peptides comprising the predicted principal neutralizing determinant (PND) in new African and North American HIV-1 clones were tested in ELISA for reactivity with ninety six serum samples from asymptomatic donors in six selected localities in Uganda. Irrespective of the geographical origin of the samples, th...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01322666
更新日期:1995-01-01 00:00:00
abstract::We present here the results of the analysis of the complete genome sequence of a lytic bacteriophage, vB_ButM_GuL6, which is the first virus isolated from Buttiauxella. Electron microscopy revealed that vB_ButM_GuL6 belongs to the family Myoviridae, order Caudovirales. The genome of vB_ButM_GuL6 is a linear, circularl...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-020-04780-7
更新日期:2020-11-01 00:00:00
abstract::In this study, we isolated a novel virulent Escherichia phage, SRT7. Its genome is a double-stranded linear DNA molecule containing 39,883 bp. Direct terminal repeats with a length of 175 bp, are present at both ends of the genome. The G+C content is 50.54%. Forty-seven putative protein coding genes were identified. N...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-019-04182-4
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journal_title:Archives of virology
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doi:10.1007/s00705-013-1810-8
更新日期:2014-02-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-012-1426-4
更新日期:2012-12-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01317202
更新日期:1992-01-01 00:00:00
abstract::To understand the mode of persistent infection of Seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. When 1-day-old rats were inoculated with the KI-83-262 strain, the S segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01718634
更新日期:1996-01-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章,评审
doi:10.1007/s00705-010-0863-1
更新日期:2011-02-01 00:00:00
abstract::An apparently single rotavirus A strain possessing a genotype constellation of G8-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2 abruptly emerged, caused diarrhoea in children requiring hospitalisation, and increased to reach 27 % of strains detected during the first half of 2015 in Vietnam. ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-015-2682-x
更新日期:2016-02-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01320782
更新日期:1982-01-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-004-0439-z
更新日期:2005-03-01 00:00:00
abstract::Two Citrus exocortis viroid isolates (CEVd-s and CEVd-129) that induce severe and mild symptoms in Gynura aurantiaca, respectively, have been characterized. They present nucleotide sequences in the pathogenicity motifs P(L), C and P(R) similar to those of "Class A" and "Class B". Infectivity and symptom expression in ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-007-0958-5
更新日期:2007-01-01 00:00:00
abstract::A total of 472 samples from domestic pigs collected in China from 2015 to 2018 were tested for the presence of porcine circovirus types 2 and 3 (PCV2 and PCV3, respectively) by conventional polymerase chain reaction analysis. The prevalence of PCV2, PCV3, and PCV2/3 co-infection was 50.0%, 13.3%, and 6.78%, respective...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-019-04336-4
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310917
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journal_title:Archives of virology
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310830
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01314489
更新日期:1977-01-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050050610
更新日期:1999-01-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-020-04927-6
更新日期:2021-01-04 00:00:00
abstract::BHK monolayer and suspension cell populations maintained in different laboratories were found to vary in their susceptibility to infection with three strains of foot-and-mouth disease virus (FMDV). The susceptibility of parent cell populations was compared with that of individual clones of cells derived from them. The...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01320756
更新日期:1980-01-01 00:00:00
abstract::Four epidemic seasons of rotaviruses were studied in Helsinki during 1986-1990. This is the first Scandinavian study, where both electropherotypes and serotypes are determined. Out of 5316 fecal specimens 769 (14.5%) rotavirus positive samples were detected by electron microscopy. Of these, 645 isolates (83.9%) gave a...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01314964
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01718332
更新日期:1996-01-01 00:00:00
abstract::A flexuous virus was isolated from cultivated Phaius flavus Lindl. plants in Japan with a latent infection. The virus was assigned to the genus Potexvirus based on morphology and analysis of its complete nucleotide sequence. The genome is 5,816 nucleotides in length, excluding the 3'-terminal poly (A) tail, and contai...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-007-0010-9
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-007-1003-4
更新日期:2007-01-01 00:00:00
abstract::To date, most members of the Siphoviridae family of bacteriophages remain unclassified, including the 46 staphylococcal phages for which the complete genome sequences have been deposited in public databases. Comparative nucleotide and protein sequence analysis, in addition to available data on phage morphology, allowe...
journal_title:Archives of virology
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00