DNA vaccines encoding proteins from wild-type and attenuated canine distemper virus protect equally well against wild-type virus challenge.

Abstract:

:Immunity induced by DNA vaccines containing the hemagglutinin (H) and nucleoprotein (N) genes of wild-type and attenuated canine distemper virus (CDV) was investigated in mink (Mustela vison), a highly susceptible natural host of CDV. All DNA-immunized mink seroconverted, and significant levels of virus-neutralizing (VN) antibodies were present on the day of challenge with wild-type CDV. The DNA vaccines also primed the cell-mediated memory responses, as indicated by an early increase in the number of interferon-gamma (IFN-γ)-producing lymphocytes after challenge. Importantly, the wild-type and attenuated CDV DNA vaccines had a long-term protective effect against wild-type CDV challenge. The vaccine-induced immunity induced by the H and N genes from wild-type CDV and those from attenuated CDV was comparable. Because these two DNA vaccines were shown to protect equally well against wild-type virus challenge, it is suggested that the genetic/antigenic heterogeneity between vaccine strains and contemporary wild-type strains are unlikely to cause vaccine failure.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Nielsen L,Jensen TH,Kristensen B,Jensen TD,Karlskov-Mortensen P,Lund M,Aasted B,Blixenkrone-Møller M

doi

10.1007/s00705-012-1375-y

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1887-96

issue

10

eissn

0304-8608

issn

1432-8798

journal_volume

157

pub_type

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