Abstract：
:During infection with herpes simplex virus type 1 (HSV-1) the activity of tyrosine hydroxylase (TH) in PC12 pheochromocytoma cells was initially depressed reaching a nadir at 6 hours post-inoculation, but recovered rapidly with a return to baseline activity by 8 to 9 hours post-inoculation. Subsequently, TH activity again fell with a second more variable rise in activity occurring at 24 hours post-inoculation. Studies with metabolic inhibitors and 2 temperature-sensitive viral mutants indicated that these alterations of TH activity were dissociated from morphological cytopathology and likely required expression of "late" viral gene products. Immunotitration using anti-TH antibody suggested that early depression of TH activity resulted principally from loss of enzyme protein rather than simple enzyme inactivation, and that reconstitution of activity at 9 hours was related to augmented enzyme synthesis. These observations illustrate the complexity of perturbed cellular metabolism during HSV-1 infection and suggest involvement of two unexpected processes: alteration of a specialized cell function as a result of viral genes expressed late in the replicative cycle, and augmented synthesis of a cell-coded gene product during the course of infection.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Rubenstein R,Price RW,Joh Tdoi
10.1007/BF01310965subject
Has Abstractpub_date
1985-01-01 00:00:00pages
65-82issue
1-2eissn
0304-8608issn
1432-8798journal_volume
83pub_type
杂志文章abstract：:Hepatitis E virus (HEV) is an unclassified, plus-strand RNA virus whose genome contains three open reading frames (ORFs). ORF1, the 5' proximal ORF of HEV, encodes nonstructural proteins involved in RNA replication which share homology with the products of the corresponding ORF of members of the alphavirus-like superf...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050070093
更新日期：2000-01-01 00:00:00
abstract：:A comparison of 15 field isolates of grapevine leafroll-associated virus 5 (GLRaV-5) was conducted, based on the analysis of nucleotide sequences of two viral ORFs: the coat protein (CP) and the heat shock protein 90 homolog (HSP90h). After amplification and cloning, the population of viral sequences was analyzed for ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1371-2
更新日期：2012-09-01 00:00:00
abstract：:As a prerequisite for development of improved vaccines and diagnostic tools for control of the fish pathogen koi herpesvirus, or cyprinid herpesvirus 3 (CyHV-3), we have started to identify putative viral envelope and capsid proteins. The complete or partial CyHV-3 open reading frames ORF25, ORF65, ORF92, ORF99, ORF13...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2190-4
更新日期：2014-12-01 00:00:00
abstract：:Japanese encephalitis virus (JEV) is a zoonotic pathogen transmitted by Culex mosquitoes and is the leading cause of viral encephalitis in humans. JEV infection of swine, which are the main amplifying hosts for JEV, can cause reproductive failure in sows; in boars it can cause testitis and infertility. The prevalence ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-019-04218-9
更新日期：2019-06-01 00:00:00
abstract：:Murine flank scarification with HSV-1 and -2 results in primary lesions at the site of inoculation within three days and lesions at secondary sites within four days. The severity of the infection can be given a numerical value or "score" which is derived from the number and size of these lesions. Using this model, we ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050030
更新日期：2000-01-01 00:00:00
abstract：:To determine the prevalence of enteroviruses in aquatic environments in Shenzhen, water samples were collected monthly from April 2010 to December 2011. After concentration by the filter adsorption-beef extract elution method, the enteroviruses were propagated in RD cells. Thirty-five of 105 water samples (33.33 %) we...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1611-0
更新日期：2013-06-01 00:00:00
abstract：:IG 1, a temperate phage of Bacillus subtilis, is strongly induced from its lysogens by 6-(p-hydroxyphenylazo)-uracil, an azopyrimidine known as selectively inhibiting the B. subtilis DNA polymerase III. IG 1 phages originated either by induction or infection multiply, abundantly, in the presence of that azopyrimidine,...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01316671
更新日期：1990-01-01 00:00:00
abstract：:Newborn WKA rats given a single intraperitoneal injection of MMC treated TARS-1, a rat T cell line producing HTLV-I, were shown to accumulate high titred antibodies specific for HTLV-I. Adult WKA rats rejected TARS-1 transplant with transient appearance of anti-HTLV-I antibodies. However, rats maintained under daily a...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314420
更新日期：1987-01-01 00:00:00
abstract：:Recently, a novel reassortant virus, influenza A(H3N2)v [A(H3N2)v], was identified as the causative pathogen in 307 human cases of influenza in the United States. A(H3N2)v contains the matrix gene from the 2009 pandemic H1N1 (pH1N1) virus, while its other genes originate from H3N2 viruses with triple-reassorted intern...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1571-9
更新日期：2013-11-01 00:00:00
abstract：:JC virus (JCV) strains worldwide can be classified into various genotypes based on DNA sequence variations. To define the domains of the four major JCV genotypes in Asia, we collected urine samples at six unstudied sites: three in southeastern Asia, two in the central highlands and one in central Asia. DNA was extract...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s705-002-8299-4
更新日期：2002-01-01 00:00:00
abstract：:To understand the mode of persistent infection of Seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. When 1-day-old rats were inoculated with the KI-83-262 strain, the S segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01718634
更新日期：1996-01-01 00:00:00
abstract：:Here, we report a novel member of the genus Polerovirus, zucchini aphid-borne yellows virus (ZABYV), which was identified in zucchini grown for seed production in the Xinjiang Uygur Autonomous Region, China. The complete nucleotide sequence of the ZABYV genome was determined and found to be 5,792 nucleotides in length...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-019-04217-w
更新日期：2019-08-01 00:00:00
abstract：:The Karens, or 'old settlers', migrated from Myanmar to Andaman and Nicobar islands 80 years ago. A high HBV exposure rate among them has been reported. A study of 34 HBsAg carriers was done to investigate the origin of HBV infection among the Karens. RFLP-based genotyping was confirmed by sequencing and phylogenetic ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-006-0910-0
更新日期：2007-01-01 00:00:00
abstract：:The gene encoding the capsid protein of a genogroup I Norwalk-like virus (NLV) (Hu/NLV/Stav/95/Nor) was cloned and expressed in insect cells using a baculovirus vector. The His-tagged recombinant capsid protein (rStav) was antigenic and immunogenic, showed an apparent molecular weight of approximately 68 kD in protein...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050665
更新日期：2000-01-01 00:00:00
abstract：:TT virus (TTV), the first human circovirus to be discovered, appears to be present in most people; less is known about the prevalence of the related TTV-like mini virus (TLMV). A sensitive nested PCR, specific for TLMV, detected the virus in 48% of 201 sera (Norwegian blood donors) previously found to have a 90% preva...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s705-002-8310-6
更新日期：2002-01-01 00:00:00
abstract：:Infectious bursal disease virus (IBDV), a member of the family Birnaviridae, is a non-enveloped, double-stranded RNA virus. Viral protein 1 (VP1), the putative RNA-dependent RNA polymerase, occurs in virions both as a free polypeptide and as a genome-linked protein, called VPg. To gain more insight in its function, we...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-004-0365-0
更新日期：2004-11-01 00:00:00
abstract：:Four distinct double-stranded (ds) RNA bands were extracted from leaves of Raphanus sativus-root cv. Yidianhong [corrected] with yellowing at the leaf edge in China. Purified viral particles of 28-30 nm in diameter contained dsRNA segments with the same number and mobility as these extracted directly from radish leave...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0685-8
更新日期：2006-05-01 00:00:00
abstract：:In 1991 and 1992, H1N2 influenza A viruses were isolated from the lungs of pigs with overt signs of respiratory disease at farms in the Chiba and Kanagawa prefectures of Japan. To determine the genetic origin of these isolates, we phylogenetically analyzed partial nucleotide sequences of their genes. The results indic...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050415
更新日期：1998-01-01 00:00:00
abstract：:Feline calicivirus (FCV) is a highly contagious pathogen that causes oral and upper respiratory tract disease in cats. Despite widespread vaccination, the prevalence of FCV remains high. Furthermore, a high gene mutation rate has led to the emergence of variants, and some infections are lethal. To date, there is no ef...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2534-8
更新日期：2015-12-01 00:00:00
abstract：:Strains of an influenza H10N4 virus have been isolated during an outbreak of a respiratory disease in mink on the south-east coast of Sweden. This was the first example of a disease in mammals caused by the H10 subtype. We compared the A/mink/Sweden/84 strain with two recent avian H10N4 isolates, one from fowl and ano...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01318353
更新日期：1990-01-01 00:00:00
abstract：:A persistent, defective infection by an unknown strain of Newcastle disease virus (NDV) appeared accidentally in established lines of pig, ox and sheep kidney cells. Virus particles released from the persistently infected cells were not infectious and were deficient in neuraminidase activity. Synthesis of some of the ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01318009
更新日期：1976-01-01 00:00:00
abstract：:Foot-and-mouth disease virus (FMDV) causes a highly contagious viral disease of cloven-hoofed animals, which has a considerable socio-economic impact on the countries affected. In addition, persistent infection can occur following clinical or sub-clinical disease in either vaccinated or non-vaccinated cattle. The mech...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-002-0867-6
更新日期：2002-11-01 00:00:00
abstract：:The modes of molecular evolution of the coat protein (CP) and 3' non-coding region (NCR) were investigated in Bean yellow mosaic virus (BYMV) isolates, including a new pathotype from blue passion fruit. In phylogenetic analysis, the new pathotype did not cluster with pathotypes or host groups described previously. Int...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-009-0485-7
更新日期：2009-01-01 00:00:00
abstract：:The small intestine of piglets orally infected with rotavirus was examined by electron microscopy 18, 24, 48 and 60 hours after infection. At 18 and 24 hours after infection columnar epithelial cells covered the villi. Infected epithelial cells tended to be less electron-dense than uninfected cells and were more numer...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317902
更新日期：1979-01-01 00:00:00
abstract：:Betanodaviruses, members of the family Nodaviridae, have small positive-stranded bipartite RNA genomes and are the causal agent of viral nervous necrosis (VNN) in many species of marine farmed fish. In the aquaculture industry, outbreaks of betanodavirus infection and spread in larval and juvenile fish result in devas...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-007-1061-7
更新日期：2007-01-01 00:00:00
abstract：:A state of persistent infection with parainfluenza type 1 virus (6/94 strain) was established in cultures of human and bovine brain cells. Following primary infection of human brain cells, viral cytopathic effect (CPE) and hemadsorption (HAD) depended on the multiplicity of infection. After persistent infection was es...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317954
更新日期：1976-01-01 00:00:00
abstract：:The aim of this study was to evaluate the long-term effectiveness of first-line antiretroviral therapy in HIV/AIDS patients in Southeast China. A total of 450 eligible patients were selected to initiate first-line antiretroviral therapy from February 2005 through August 2009. During the study period from 2009 through ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2583-z
更新日期：2015-11-01 00:00:00
abstract：:The bisegmented genome of a putative double-stranded (ds) RNA virus from Ustilaginoidea virens was sequenced and analyzed. The larger genomic segment of 2112 bp encodes a putative RNA-dependent RNA polymerase (RdRp, 628 aa), and the smaller one of 2082 bp encodes a putative coat protein (CP) of 539 aa. The 5' untransl...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-1991-9
更新日期：2014-07-01 00:00:00
abstract：:Reverse transcription coupled with the polymerase chain reaction (RT-PCR) was used for the rapid laboratory diagnosis of pestivirus infections. A direct DNA sequencing method was developed for the analysis of the amplified cDNA from the 5' noncoding region of the viral genome. 70 pestivirus strains were compared in th...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01309467
更新日期：1994-01-01 00:00:00
abstract：:Fragaria (strawberry) and Rubus species (blackberry, wild blackberry, red raspberry and black raspberry) were thought to be infected with distinct isolates of Tobacco streak virus (TSV). Employing serology and nucleic acid hybridization it has been shown that these isolates form a cluster distinct from other strains o...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-004-0330-y
更新日期：2004-10-01 00:00:00
