Abstract:
:A persistent, defective infection by an unknown strain of Newcastle disease virus (NDV) appeared accidentally in established lines of pig, ox and sheep kidney cells. Virus particles released from the persistently infected cells were not infectious and were deficient in neuraminidase activity. Synthesis of some of the virus-specified proteins in the persistently infected cells was temperature-sensitive. Co-cultivation of mixed populations of carrier cells and healthy chick embryo cells induced cell fusion with the formation of multinucleate heterokaryons and intra-nuclear inclusions. The development of inclusions in the chicken nuclei was not accompanied by 'rescue' of infectious NDV.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Fraser G,Edwards HH,McNulty MS,Ruben JMdoi
10.1007/BF01318009subject
Has Abstractpub_date
1976-01-01 00:00:00pages
147-57issue
1-2eissn
0304-8608issn
1432-8798journal_volume
50pub_type
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