Modes of Seoul virus infections: persistency in newborn rats and transiency in adult rats.

Abstract:

:To understand the mode of persistent infection of Seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. When 1-day-old rats were inoculated with the KI-83-262 strain, the S segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 days post inoculation (d.p.i.) by nested reverse transcriptase PCR. On the other hand, when 7-week-old rats were infected with this virus, viral genome was detected only in the lungs from 3 to 50 d.p.i. The neutralizing antibody titers of rats inoculated at 1-day of age were higher than those of rats inoculated at 7 weeks of age. In both age groups, however, the IgG avidity of antibody increased along with the course of infection. We found that urban rats (Rattus norvegicus) infected early in life harbored the virus for more than 6 months.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Kariwa H,Kimura M,Yoshizumi S,Arikawa J,Yoshimatsu K,Takashima I,Hashimoto N

doi

10.1007/BF01718634

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

2327-38

issue

12

eissn

0304-8608

issn

1432-8798

journal_volume

141

pub_type

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