Abstract:
:To understand the mode of persistent infection of Seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. When 1-day-old rats were inoculated with the KI-83-262 strain, the S segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 days post inoculation (d.p.i.) by nested reverse transcriptase PCR. On the other hand, when 7-week-old rats were infected with this virus, viral genome was detected only in the lungs from 3 to 50 d.p.i. The neutralizing antibody titers of rats inoculated at 1-day of age were higher than those of rats inoculated at 7 weeks of age. In both age groups, however, the IgG avidity of antibody increased along with the course of infection. We found that urban rats (Rattus norvegicus) infected early in life harbored the virus for more than 6 months.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Kariwa H,Kimura M,Yoshizumi S,Arikawa J,Yoshimatsu K,Takashima I,Hashimoto Ndoi
10.1007/BF01718634subject
Has Abstractpub_date
1996-01-01 00:00:00pages
2327-38issue
12eissn
0304-8608issn
1432-8798journal_volume
141pub_type
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