Sequence analysis of the glycoprotein E gene of varicella-zoster virus strains of clades 1, 3 and 5.

Abstract:

:Eighty-six varicella-zoster virus (VZV) strains of clades 1, 3 and 5, isolated from varicella and zoster patients in Germany, were analyzed by sequencing the glycoprotein E gene. Four novel non-synonymous and 10 novel synonymous mutations were detected. Of these, two synonymous (C513T, C885T) and two non-synonymous mutations (T485G, C524T) were located within the coding regions of e1 and c1. The profile of single-nucleotide polymorphisms was found to be significantly associated with the VZV clades 1, 3 and 5.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Sauerbrei A,Wiesener N,Zell R,Wutzler P

doi

10.1007/s00705-010-0864-0

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

505-9

issue

3

eissn

0304-8608

issn

1432-8798

journal_volume

156

pub_type

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