Abstract:
:A state of persistent infection with parainfluenza type 1 virus (6/94 strain) was established in cultures of human and bovine brain cells. Following primary infection of human brain cells, viral cytopathic effect (CPE) and hemadsorption (HAD) depended on the multiplicity of infection. After persistent infection was established the virus rapidly became cell-associated; no CPE occurred and no viral antigen was detectable by HAD, immunofluorescence (FA), or immunoprecipitation. Infectious virus could be recovered only by fusion or cocultivation. This was in marked contrast with infected bovine brain cells, where, following primary infection, little or no CPE occurred. A productive infection rapidly evolved and persisted without CPE, but with 100 per cent HAD and FA positive cells.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Wroblewska Z,Santoli D,Gilden D,Lewandowski L,Koprowski Hdoi
10.1007/BF01317954subject
Has Abstractpub_date
1976-01-01 00:00:00pages
287-303issue
4eissn
0304-8608issn
1432-8798journal_volume
50pub_type
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journal_title:Archives of virology
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doi:10.1007/BF01310895
更新日期:1986-01-01 00:00:00
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journal_title:Archives of virology
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abstract::Bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) are two closely related alphaherpesviruses. BoHV-1 causes several syndromes in cattle, including respiratory disease and sporadic cases of encephalitis, whereas BoHV-5 is responsible for meningoencephalitis in calves. Although both viruses are neurotropic, they differ...
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更新日期:1989-01-01 00:00:00
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更新日期:1991-01-01 00:00:00
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