Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice.

Abstract:

:A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Tracy S,Chapman NM,Tu Z

doi

10.1007/BF01317202

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

399-409

issue

3-4

eissn

0304-8608

issn

1432-8798

journal_volume

122

pub_type

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