Abstract：
:A 5-year-old female Yorkshire terrier dog died a few days following hernia and ovariohysterectomy surgeries. Necropsy performed on the dog revealed that the surgeries were not the cause of death; however, degenerative viral hepatitis, showing intranuclear inclusion bodies in hepatic cells, was observed in histopathologic examination. Several diagnostic methods were used to screen for the cause of disease, and minute virus of canines (MVC) was detected in all parenchymal organs, including the liver. Other pathogens that may cause degenerative viral hepatitis were not found. Infection with MVC was confirmed by in situ hybridization, which revealed the presence of MVC nucleic acid in the liver tissue of the dog. Through sequencing and phylogenetic analysis of the nearly complete genome sequence, the strain was found to be distinct from other previously reported MVC strains. These results indicate that this novel MVC strain might be related to degenerative viral hepatitis in dogs.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Choi JW,Jung JY,Lee JI,Lee KK,Oem JKdoi
10.1007/s00705-016-2895-7subject
Has Abstractpub_date
2016-08-01 00:00:00pages
2299-304issue
8eissn
0304-8608issn
1432-8798pii
10.1007/s00705-016-2895-7journal_volume
161pub_type
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