当前位置： SCI文献检索 > ARCHIVES OF VIROLOGY期刊下所有文献 > The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.

The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.

Abstract：

:Our previous studies demonstrated that hepatitis E virus (HEV) requires the multivesicular body (MVB) pathway to release virus particles, suggesting that HEV utilizes the cellular ESCRT machinery in the cytoplasm, not at the cell surface, to be released from infected cells. In this study, we generated a murine monoclonal antibody (mAb) against the membrane-associated HEV particles to examine whether the membrane is derived from intracellular vesicles or the cell surface. An established mAb, TA1708, was found to capture the membrane-associated HEV particles, but not the membrane-dissociated particles or fecal HEV, in an immunocapture RT-PCR assay. Furthermore, digitonin treatment confirmed that the membrane on the surface of cell-culture-generated HEV particles was a lipid membrane. Double immunofluorescence staining revealed that mAb TA1708 specifically recognizes trans-Golgi network protein 2 (TGOLN2), an intracellular antigen derived from the trans-Golgi network. Supporting these findings, HEV particles with lipid membranes and ORF3 proteins on their surface were found abundantly in the lysates of HEV-infected cells. These results indicate that HEV forms membrane-associated particles in the cytoplasm, most likely by budding into intracellular vesicles, and that the released HEV particles with a lipid membrane retain the antigenicity of TGOLN2 on their surface.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Nagashima S,Takahashi M,Jirintai S,Tanggis,Kobayashi T,Nishizawa T,Okamoto H

doi

10.1007/s00705-013-1912-3

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

979-91

issue

5

eissn

0304-8608

issn

1432-8798

journal_volume

159

pub_type

杂志文章

相关文献

ARCHIVES OF VIROLOGY文献大全
  • Co-expression of hepatitis B virus antigens by a non-defective adenovirus vaccine vector.

    abstract：:Adenovirus type 7 vaccine strain was engineered to express foreign antigens from both the E3 early promoter in the E3 region and the major late promoter inserted between the E4 region and the right inverted terminal repeat. This multiple expression vector was used to express hepatitis B core antigen (HBcAg), hepatitis...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/BF01311300

    authors： Ye WW,Mason BB,Chengalvala M,Cheng SM,Zandle G,Lubeck MD,Lee SG,Mizutani S,Davis AR,Hung PP

    更新日期：1991-01-01 00:00:00

  • Molecular phylogenetic analysis of Barley yellow mosaic virus.

    abstract：:Complete nucleotide sequences of three strains (I, III, and IV) of Barley yellow mosaic virus (BaYMV) isolated in Japan were determined. The length of the genome was the same among the three strains; RNA1 was 7,642 nt and RNA2 was 3,585 nt. The molecular phylogenetic analysis showed that strain I was most closely rela...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-008-0163-1

    authors： Nishigawa H,Hagiwara T,Yumoto M,Sotome T,Kato T,Natsuaki T

    更新日期：2008-01-01 00:00:00

  • Nanovirus-alphasatellite complex identified in Vicia cracca in the Rhône delta region of France.

    abstract：:Nanoviruses are multi-component plant-infecting single-stranded DNA viruses. Using a viral metagenomics-informed approach, a new nanovirus and two associated alphasatellite molecules have been identified in an uncultivated asymptomatic Vicia cracca plant in the Rhône region of France. This novel nanovirus genome inclu...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-017-3634-4

    authors： Gallet R,Kraberger S,Filloux D,Galzi S,Fontes H,Martin DP,Varsani A,Roumagnac P

    更新日期：2018-03-01 00:00:00

  • Rotavirus serotypes and electropherotypes in Finland from 1986 to 1990.

    abstract：:Four epidemic seasons of rotaviruses were studied in Helsinki during 1986-1990. This is the first Scandinavian study, where both electropherotypes and serotypes are determined. Out of 5316 fecal specimens 769 (14.5%) rotavirus positive samples were detected by electron microscopy. Of these, 645 isolates (83.9%) gave a...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/BF01314964

    authors： Maunula L,von Bonsdorff CH

    更新日期：1995-01-01 00:00:00

  • Polypeptide patterns of infectious bronchitis virus serotypes fall into two categories. Brief report.

    abstract：:Molecular weights of six major polypeptides of infectious bronchitis virus (IBV) are: 1. 75,000; 2. 50,000; 3. 45,000; 4. 35,000; 5. 28,000 or 24,000, and 6. 22,000 dalton. According to the mobility of protein 5 the polypeptide patterns of IBV serotypes fall into two main categories. ...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/BF01315022

    authors： Nagy E,Lomniczi B

    更新日期：1979-01-01 00:00:00

  • Complete genome sequence of jacquemontia yellow vein virus, a novel begomovirus infecting Jacquemontia tamnifolia in Venezuela.

    abstract：:Wild plants of the family Convolvulaceae are hosts for a few New World begomoviruses (genus Begomovirus, family Geminiviridae). In this work, we report the complete genome sequence of a new begomovirus infecting the wild convolvulaceous plant Jacquemontia tamnifolia in Venezuela. The cloned bipartite genome showed the...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-017-3372-7

    authors： Fiallo-Olivé E,Chirinos DT,Geraud-Pouey F,Navas-Castillo J

    更新日期：2017-08-01 00:00:00

  • Detection and genome sequence of a new betapartitivirus associated with Cucurbitaria piceae Borthw. fungus causing bud blight of spruce in the Czech Republic.

    abstract：:A new bisegmented dsRNA virus has been detected in shoots of blue spruce with bud blight disease symptoms and infection by Cucurbitaria piceae (Bortw.) fungus. The virus genome consists of two segments that are 2071 and 2257 nt long, encoding the putative RNA polymerase and capsid protein, respectively. Rosellinia nec...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-015-2692-8

    authors： Petrzik K,Koloniuk I,Sarkisova T,Hrabáková L

    更新日期：2016-05-01 00:00:00

  • Phylogenetic tracking of current porcine epidemic diarrhea virus (PEDV) strains in the Philippines.

    abstract：:To trace the possible route of introduction of porcine epidemic diarrhea virus (PEDV), the phylogenetic relationships of PEDV strains in the regions of epidemicity in the Philippines to PEDV strains that are endemic in other countries were investigated. Partial nucleotide sequences of the S1 spike gene was determined ...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-016-2938-0

    authors： Paraguison-Alili R,Domingo CY

    更新日期：2016-09-01 00:00:00

  • Molecular diversity of the coat protein-encoding region of Barley yellow dwarf virus-PAV and Barley yellow dwarf virus-MAV from Latvia and Sweden.

    abstract：:The sequence variability of Barley yellow dwarf virus-PAV (PAV) and Barley yellow dwarf virus-MAV (MAV) was studied by comparing 502 nucleotides from the coat protein-encoding region of six isolates from Latvia and four from Sweden. The diversity within MAV was low (>97% sequence identity), also when compared to isola...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-003-0242-2

    authors： Bisnieks M,Kvarnheden A,Sigvald R,Valkonen JP

    更新日期：2004-04-01 00:00:00

  • Comparing the effect of Toll-like receptor agonist adjuvants on the efficiency of a DNA vaccine.

    abstract：:We have investigated whether poly(I:C) Toll-like receptor 3 (TLR3) and resiquimod Toll-like receptor 7 (TLR7) agonists can serve as vaccine adjuvants and promote the efficiency of therapeutic DNA vaccination against tumors expressing the human papilloma virus 16 (HPV-16) E7 protein. For this purpose, C57BL/6 mice were...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-014-2024-4

    authors： Sajadian A,Tabarraei A,Soleimanjahi H,Fotouhi F,Gorji A,Ghaemi A

    更新日期：2014-08-01 00:00:00

  • Genomic characterization of cycad leaf necrosis virus, the first badnavirus identified in a gymnosperm.

    abstract：:A previously undescribed badnavirus was isolated from Zamia fischeri showing symptoms of chlorosis, necrosis, and ringspot. The virus has bacilliform virions 30 nm in diameter and averaging 120 nm in length. The viral genome is 9227 bp in length and contains three open reading frames characteristic of members of the g...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-020-04630-6

    authors： Alvarez-Quinto RA,Lockhart BEL,Fetzer JL,Olszewski NE

    更新日期：2020-07-01 00:00:00

  • Apple chlorotic leaf spot virus 50 kDa protein is targeted to plasmodesmata and accumulates in sieve elements in transgenic plant leaves.

    abstract：:We investigated the in situ localization of the 50 kDa protein encoded by ORF2 of Apple chlorotic leaf spot virus (ACLSV) genome which is thought to be a movement protein. In immunogold electron microscopy of ACLSV-infected Chenopodium quinoa leaves, the 50 kDa protein was localized on plasmodesmata and nearby cytopla...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s007050050660

    authors： Yoshikawa N,Oogake S,Terada M,Miyabayashi S,Ikeda Y,Takahashi T,Ogawa K

    更新日期：1999-01-01 00:00:00

  • Temperature sensitivity of herpes simplex virus type 1 is a tissue-dependent phenomenon.

    abstract：:The temperature sensitivity of herpes simplex virus type 1 (HSV-1) was assessed in primary cultures of mouse central nervous system (MNS) cells and mouse embryo cells (MEC). Infectious yields were determined and the ultrastructural morphogenesis of HSV-1 particles was compared following incubation at 37 or 40.5 degree...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/BF01309574

    authors： Cole NL

    更新日期：1992-01-01 00:00:00

  • The phylogenetic and recombinational analysis of beak and feather disease virus Taiwan isolates.

    abstract：:Beak and feather disease virus (BFDV) is an avian circovirus, and it has a single-stranded DNA genome. It causes a fatal disease in parrots called psittacine beak and feather disease (PBFD). After screening of samples collected from Taiwan using PCR, complete genome sequences of isolates from 21 samples from various s...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-016-2963-z

    authors： Huang SW,Chiang YC,Chin CY,Tang PC,Liu PC,Wang CY

    更新日期：2016-11-01 00:00:00

  • Antiviral activity of baicalin against influenza A (H1N1/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase.

    abstract：:Scutellaria baicalensis Georgi, a Chinese herbal decoction, has been used for the treatment of the common cold, fever and influenza virus infections. In previous studies, we found that oral administration of baicalein resulted in the inhibition of influenza A virus replication in vivo, which was linked to baicalin in ...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-014-2192-2

    authors： Ding Y,Dou J,Teng Z,Yu J,Wang T,Lu N,Wang H,Zhou C

    更新日期：2014-12-01 00:00:00

  • Characterization of rat brain cellular membrane components acting as receptors for vesicular stomatitis virus. Brief report.

    abstract：:The chemical nature of the binding sites for vesicular stomatitis virus (VSV) was studied by measuring the ability of solubilized rat brain cell membranes (SRBM) to compete with cultured cells for viral binding. SRBM significantly reduced both binding and infectivity of VSV. After separation of protein and lipid compo...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/BF01311075

    authors： Conti C,Mastromarino P,Ciuffarella MG,Orsi N

    更新日期：1988-01-01 00:00:00

  • Establishment of persistent foot-and-mouth disease virus (FMDV) infection in MDBK cells.

    abstract：:In addition to acute infection and disease, foot-and-mouth disease virus (FMDV) can cause persistent infection in ruminants. Such "carrier" animals represent a potential risk for FMDV transmission to susceptible animals. However, the mechanisms and the factors that determine FMDV persistence remain unknown. We describ...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-015-2526-8

    authors： Kopliku L,Relmy A,Romey A,Gorna K,Zientara S,Bakkali-Kassimi L,Blaise-Boisseau S

    更新日期：2015-10-01 00:00:00

  • Porcine circovirus type 2 ORF5 protein induces endoplasmic reticulum stress and unfolded protein response in porcine alveolar macrophages.

    abstract：:Porcine circovirus type 2 (PCV2) is the essential infectious agent causing porcine circovirus-associated disease (PCVD) in pigs and one of the important viruses that severely jeopardize the swine husbandry industry. PCV2 elicits the unfolded protein response (UPR) via activation of the PERK pathway, and its capsid pro...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-019-04185-1

    authors： Ouyang Y,Xu L,Lv J,Hou Y,Fan Z,Xu P,Jiang Y,Wu M,Li R,Zhang Y,Guo K

    更新日期：2019-05-01 00:00:00

  • Inhibition of betanodavirus infection by inhibitors of endosomal acidification.

    abstract：:Betanodaviruses, members of the family Nodaviridae, have small positive-stranded bipartite RNA genomes and are the causal agent of viral nervous necrosis (VNN) in many species of marine farmed fish. In the aquaculture industry, outbreaks of betanodavirus infection and spread in larval and juvenile fish result in devas...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-007-1061-7

    authors： Adachi K,Ichinose T,Takizawa N,Watanabe K,Kitazato K,Kobayashi N

    更新日期：2007-01-01 00:00:00

  • The effect of temperature on production and function of bovine interferons.

    abstract：:Subnormal temperatures were found to depress the production of interferon by bovid herpesvirus 2 (BHV-2)-infected bovine testicular cells, bovine peripheral blood leukocytes, and bovine monocytes, as well as by BHV-2 antigen-stimulated immune peripheral blood leukocytes. Interferon titers generated at 30 degrees C wer...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/BF01311164

    authors： Letchworth GJ 3rd,Carmichael LE

    更新日期：1984-01-01 00:00:00

  • Complete nucleotide sequence of a new potexvirus, "Phaius virus X", isolated from Phaius flavus Lindl.

    abstract：:A flexuous virus was isolated from cultivated Phaius flavus Lindl. plants in Japan with a latent infection. The virus was assigned to the genus Potexvirus based on morphology and analysis of its complete nucleotide sequence. The genome is 5,816 nucleotides in length, excluding the 3'-terminal poly (A) tail, and contai...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-007-0010-9

    authors： Kawakami K,Fuji S,Miyoshi K

    更新日期：2008-01-01 00:00:00

  • Genomic RNA constellation of recently emerging serotype G14 equine rotavirus strains in Japan that is highly homologous with prototype G3 and G14 strains previously identified in the United States of America.

    abstract：:Serotype G14 was once considered to be uncommon among equine rotaviruses. While it sporadically emerged in some parts of the world, serotype G14 became the dominant G serotype among rotaviruses detected in foals with diarrhea in Japan in the late 1990s. However, it is not known how such recently emerging G14 rotavirus...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-002-0967-3

    authors： Nakagomi T,Tsunemitsu H,Imagawa H,Nakagomi O

    更新日期：2003-05-01 00:00:00

  • A real-time RT-PCR for rapid detection and quantification of mosquito-borne alphaviruses.

    abstract：:Mosquito-borne alphaviruses are widely distributed throughout the world, causing important human illnesses. Therefore, the development of methods to enable early diagnosis of infections by alphavirus is essential. We show here the development and evaluation of a quantitative real-time RT-PCR using genus-specific prime...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-016-3019-0

    authors： Romeiro MF,de Souza WM,Tolardo AL,Vieira LC,Henriques DA,de Araujo J,Siqueira CE,Colombo TE,Aquino VH,da Fonseca BA,de Morais Bronzoni RV,Nogueira ML,Durigon EL,Figueiredo LT

    更新日期：2016-11-01 00:00:00

  • Phylogenetic analysis of Vietnamese isolates of feline immunodeficiency virus: genetic diversity of subtype C.

    abstract：:Phylogenetic relationships of novel Vietnamese strains of feline immunodeficiency virus (FIV) were analysed. One Vietnamese strain was found to cluster with subtype D, which was previously known only in Japan, while the other seven strains were placed with members of subtype C. Calculation of the relative numbers of m...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-002-0954-8

    authors： Nakamura K,Suzuki Y,Ikeo K,Ikeda Y,Sato E,Nguyen NT,Gojobori T,Mikami T,Miyazawa T

    更新日期：2003-04-01 00:00:00

  • Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus.

    abstract：:Fecal virus shedding, seroconversion and histopathology were evaluated in 3-7-year-old gnotobiotic calves orally inoculated with porcine deltacoronavirus (PDCoV) (9.0-9.6 log10 genomic equivalents [GE] of OH-FD22-P5; n=4) or porcine epidemic diarrhea virus (PEDV) (10.2-12.5 log10 GE of PC21A; n=3). In PDCoV-inoculated...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s00705-017-3351-z

    authors： Jung K,Hu H,Saif LJ

    更新日期：2017-08-01 00:00:00

  • Tryptic peptide analysis of the structural proteins of a temperature-sensitive mutant derived from an HVJ (Sendai virus) carrier culture.

    abstract：:The individual structural polypeptides of HVJ (haemagglutinating virus of Japan--the Sendai strain of parainfluenza 1 virus) were examined by tryptic peptide analysis. [3H]-methionine-labelled structural proteins of the wild-type virus of HVJ (HVJ-W) and [35S]-methionine-labelled corresponding constituent proteins of ...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/BF01320600

    authors： Kimura Y

    更新日期：1979-01-01 00:00:00

  • Rescue of a bovine respiratory syncytial virus genomic RNA analog by bovine, human and ovine respiratory syncytial viruses confirms the "functional integrity" and "cross-recognition" of BRSV cis-acting elements by HRSV and ORSV.

    abstract：:The nucleotide sequences of the 3' leader and 5' trailer regions were determined for genomic RNA of bovine respiratory syncytial virus (BRSV) strain A-51908. The leader and trailer sequences are '45' and '161' nucleotides in length, respectively. The functionality of BRSV leader and trailer sequences and their recogni...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s007050050719

    authors： Yunus AS,Krishnamurthy S,Pastey MK,Huang Z,Khattar SK,Collins PL,Samal SK

    更新日期：1999-01-01 00:00:00

  • Electropherotypes, serotypes, and subgroups of equine rotaviruses isolated in Japan.

    abstract：:Electropherotypes (ET), serotypes, and subgroups of equine rotaviruses isolated from foals in Japan were determined. The ETs of 136 isolates from 1981 through to 1991 were divided into six groups: ET-A-ET-F. The ET-A, -B, -C, -D, -E, and -F were present in 3, 1, 121, 9, 1, and 1 strains, respectively. Representative v...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/BF01379088

    authors： Imagawa H,Tanaka T,Sekiguchi K,Fukunaga Y,Anzai T,Minamoto N,Kamada M

    更新日期：1993-01-01 00:00:00

  • Evidence that virion-associated VP1 of avibirnaviruses contains viral RNA sequences.

    abstract：:The VP1 encoded by genomic segment B of birnaviruses is generally known to exist as a genome-linked protein (VPg) and as a "free" polypeptide of 90 kDa in virus particles. The guanylylation activity associated with infectious bursal disease virus (IBDV) was demonstrated by incubating purified virus in presence of [alp...

    journal_title：Archives of virology

    pub_type： 杂志文章

    doi：10.1007/s007050050154

    authors： Kibenge FS,Dhama V

    更新日期：1997-01-01 00:00:00

  • Distinctive features of bovine alphaherpesvirus types 1 and 5 and the virus-host interactions that might influence clinical outcomes.

    abstract：:Bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) are two closely related alphaherpesviruses. BoHV-1 causes several syndromes in cattle, including respiratory disease and sporadic cases of encephalitis, whereas BoHV-5 is responsible for meningoencephalitis in calves. Although both viruses are neurotropic, they differ...

    journal_title：Archives of virology

    pub_type： 杂志文章,评审

    doi：10.1007/s00705-019-04494-5

    authors： Marin M,Burucúa M,Rensetti D,Rosales JJ,Odeón A,Pérez S

    更新日期：2020-02-01 00:00:00