C-type RNA virus from hamster cells transformed in vitro by 1-B-D-arabinofuranosylcytosine.

Abstract:

:Evidence of type-C RNA viral activity in fetal hamster cells transformed in vitro by 1-B-D-arabinofuranosylcytosine (ara-C) after at least one in vivo passage is described. The virus possesses properties typical of other type-C RNA viruses, such as: a) morphology as determined with the electron microscope, b) presence of 70S RNA, c) enhanced expression following treatment with halogenated pyrimidines, d) group specific antigens of hamster type, and e) a buoyant density of 1.15 g per cm3. However, the virus particles are deficient in RNA-dependent DNA polymerase activity under conditions that easily detect Rauscher Leukemia virus and will infect neither hamster, rat, mouse, human nor rabbit cells. The possible role of this virus in chemical carcinogenesis of cultured hamster fetal cells is discussed.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Kouri RE,Kurtz SA,Vernon ML,Schechtman LM,Nicolson M,Klement V,Benedict WF

doi

10.1007/BF01317556

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

241-52

issue

3

eissn

0304-8608

issn

1432-8798

journal_volume

62

pub_type

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