Improved pig donor screening including newly identified variants of porcine endogenous retrovirus-C (PERV-C).

Abstract:

:Porcine endogenous retroviruses (PERV) are widely distributed in the genomes of pigs. PERV-A and PERV-B are present in all pigs. They infect human cells in vitro and therefore represent a risk for xenotransplantation when pig cells, tissues or organs are used. PERV-C infects only pig cells and is not present in the genomes of all pigs. However, PERV-A/C recombinants infecting human cells and characterized by high replication titers were found in pigs. To select PERV-C-free animals that cannot generate such recombinants, PCR-based assays were developed (Kaulitz et al., J Virol Methods, 175:60, 2011). When screening for PERV-C in German wild boars (Sus scrofa scrofa), applying these methods, a new variant of PERV-C was identified. Whereas in all 125 wild boar only the new variant of PERV-C was found, different variants were present in some landrace pigs, and most importantly, some pigs were totally free of PERV-C.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Kaulitz D,Mihica D,Adlhoch C,Semaan M,Denner J

doi

10.1007/s00705-012-1490-9

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

341-8

issue

2

eissn

0304-8608

issn

1432-8798

journal_volume

158

pub_type

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