Abstract：
:JC virus (JCV) strains worldwide can be classified into various genotypes based on DNA sequence variations. To define the domains of the four major JCV genotypes in Asia, we collected urine samples at six unstudied sites: three in southeastern Asia, two in the central highlands and one in central Asia. DNA was extracted from urine samples, and used to amplify a 610-bp region of the viral genome. For each geographical site, we determined 16 to 31 sequences, from which a phylogenetic tree was constructed to unambiguously classify detected JCV isolates into distinct genotypes. From JCV genotype profiles at the sites studied here and elsewhere, the following conclusions were drawn. Although Af2 is the major genotype in Africa, this genotype also occurs in western and central Asia. B1-b mainly occurs in western and central Asia, including the central highlands. CY occurs in northeastern Asia with the southern boundary between China and southeast Asian countries. Although SC predominates in southeastern Asia, it also occurs in northern and central Asia at lower frequencies. In addition, a few minor JCV genotypes (B1-a, B2 and B3) occur at many sites. We discuss here the anthropological and medical significance of the present findings.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Saruwatari L,Sugimoto C,Kitamura T,Ohno N,Sakai E,Shresta P,Hoa BK,Phi PT,An HP,Tuyet NT,Honjo T,Kobayashi N,Zheng HY,Takasaka T,Yogo Ydoi
10.1007/s705-002-8299-4keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
1-10issue
1eissn
0304-8608issn
1432-8798journal_volume
147pub_type
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journal_title：Archives of virology
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pub_type： 杂志文章
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01340540
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doi：10.1007/BF01384343
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-003-0184-8
更新日期：2004-02-01 00:00:00
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更新日期：2010-02-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-003-0245-z
更新日期：2004-05-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050695
更新日期：2000-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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