Involvement of glycoprotein C (gC) in adsorption of herpes simplex virus type 1 (HSV-1) to the cell.

Abstract:

:Results demonstrating involvement of glycoprotein C (gC) of herpes simplex type 1 virus (HSV-1) in attachment of the virus to the cell are presented. Monoclonal antibodies against gC-1 inhibited adsorption of gC(+)-strains. The gC(-)-mutant, MP, attached to cells but at a reduced rate. Attachment of the MP-mutant was unaffected by presence of anti-gC-1 antibody. Purified truncated gC-1 adsorbed to cells at a rate essentially the same as that of gC(+)-virus. Glycoprotein C-1 pretreated with heparin did not adsorb to cells. The results are compatible with a suggested role for gC in HSV attachment.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Svennerholm B,Jeansson S,Vahlne A,Lycke E

doi

10.1007/BF01310482

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

273-9

issue

3-4

eissn

0304-8608

issn

1432-8798

journal_volume

120

pub_type

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