Abstract：
:Since the appearance of resistance to antiretroviral treatment is unavoidable, the host cell's transcription factor NF-kappaB is a novel HIV target. The goal of this study was to characterize the effect of two immunomodulators, curcumin (Cur) and sulfasalazine (Sul), with a protease inhibitor, indinavir (IDV), on HIV-1 persistently infected CD4+ T-cells. Viral p24 antigen production, viral infectivity (tested on MAGI cells) and viral relative infectivity (viral infectivity/p24) were analysed. When used alone, both immunomodulators were able to reduce viral infectivity. When in combination, both 10 microM IDV plus 10 microM Cur and 10 microM IDV plus 250 microM Sul showed a significant reduction in viral infectivity and viral relative infectivity when compared to the reduction produced by IDV alone. Thus, the use of immunomodulators with IDV could help to reduce HIV-1 production in persistently infected cells.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Riva DA,Fernández-Larrosa PN,Dolcini GL,Martínez-Peralta LA,Coulombié FC,Mersich SEdoi
10.1007/s00705-007-0023-4subject
Has Abstractpub_date
2008-01-01 00:00:00pages
561-5issue
3eissn
0304-8608issn
1432-8798journal_volume
153pub_type
杂志文章abstract：:Equine herpesvirus 1 glycoprotein D (EHV-1 gD) expressed constitutively in mammalian cell lines had similar electrophoretic mobility to gD produced in EHV-1 infected cells but lacked a possibly complexed higher molecular weight form seen in the latter. Recombinant gD was N-terminally cleaved at the same site as gD in ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01718301
更新日期：1996-01-01 00:00:00
abstract：:Human papillomaviruses (HPVs) are responsible for the most common human sexually transmitted viral infections. Infection with high-risk HPVs, particularly HPV16, is associated with the development of cervical cancer. The papillomavirus L1 major capsid protein, the basis of the currently marketed vaccines, self-assembl...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-009-0484-8
更新日期：2009-01-01 00:00:00
abstract：:Fowl adenoviruses (FAdVs) are widely distributed in chickens in Poland and throughout the world. FAdV infections have been reported in the United States, Australia, Europe, and the Mediterranean basin. Detection of FAdVs strains is very important from the epidemiological point of view and for monitoring disease outbre...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2635-4
更新日期：2016-01-01 00:00:00
abstract：:Mentha x gracilis 'Variegata', an ornamental mint clone first described about 200 years ago, exhibits virus-like vein banding symptoms. Double-stranded RNA and virion isolations revealed the presence of three viruses in a 'Variegata' plant. Cloning and sequencing disclosed that one of the viruses was a previously unid...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0586-x
更新日期：2006-01-01 00:00:00
abstract：:To elucidate changes associated with the attenuated virulence in a modified live porcine reproductive and respiratory syndrome (PRRS) vaccine (Boehringer Ingelheim Animal Health, St. Joseph, MO), derived from an American prototype ATCC virus VR-2332, nucleotide sequence of 3' genome covering open reading frames (ORFs)...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050316
更新日期：1998-01-01 00:00:00
abstract：:To investigate the genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV) in Northern Ireland, the ORF5 gene from nine field isolates was sequenced and phylogenetically analysed. The results revealed relatively high diversity amongst isolates, with 87.6-92.2% identity between farms at the nuc...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-3886-7
更新日期：2018-10-01 00:00:00
abstract：:The value of serologic tests for diagnosis of swine influenza virus (SIV) infection has been diminished by the emergence of new subtypes and by antigenic drift within subtype. The intensive use of vaccination also has complicated interpretation of serology results. Serologic assays are needed that can detect infection...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0615-9
更新日期：2006-01-01 00:00:00
abstract：:Truncated alpha 4 genes were introduced into BHK tk- cells along with the neomycin phosphotransferase gene, that confers resistance to the eukaryotic antibiotic G418, driven by the HSV-1 beta tk promoter (beta tk- neor). Stably transformed cell lines were obtained and studied for the ability of the resident truncated ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01316907
更新日期：1993-01-01 00:00:00
abstract：:A type III Trichomonas vaginalis virus, which may be involved in transcriptional regulation of the major surface protein gene P270 of the protozoan pathogen Trichomonas vaginalis, was purified and characterized in the present study. The complete 4844-base-pair complementary DNA sequence of the viral genome reveals ove...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-010-0858-y
更新日期：2011-02-01 00:00:00
abstract：:A simple radial method based on the formerly described paper disc technique was developed for demonstration of neutralizing antibodies to enteroviruses with plaque forming ability. Sera administered by 5 microliter wire-loops to wells cut into the agar overlay of virus infected cell monolayers produced radial neutrali...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317320
更新日期：1980-01-01 00:00:00
abstract：:The complete genome of O/Akesu/58 strain of foot-and-mouth disease virus (FMDV) was sequenced. The phylogenetic analysis revealed that it is not closely related to epidemic strains or previous strains compared with reference sequences (the identities of complete VP1 nucleotide sequences range from 77.5 to 84.0%). Its ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-007-1041-y
更新日期：2007-01-01 00:00:00
abstract：:Although viral protein 3 (VP3) of chicken anaemia virus (CAV) has been well recognised as an inducer of apoptosis, viral protein 2 (VP2) of the virus has only been speculated to have apoptotic activity. This has not been verified because the open reading frame (ORF) encoding VP2 completely encompasses that encoding VP...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2542-8
更新日期：2015-10-01 00:00:00
abstract：:Human leukocyte antigen (HLA) alleles are associated with both the progression of chronic hepatitis C (CHC) and the sustained virological response (SVR) to antiviral therapy. HLA-A*02 is the most common HLA allele in people of European/Caucasian descent and the Chinese and Japanese population. Therefore, we investigat...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2361-y
更新日期：2015-04-01 00:00:00
abstract：:Hepatitis C virus (HCV) genome contains a 3'noncoding region (3'NCR) consisting of a variable region, a polypyrimidine tract (polyU/UC) and the X region. To examine the roles of 3'NCR and polyU/UC tract in the internal ribosome entry site (IRES)-mediated translation process, a variety of 3'NCRs containing different le...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0491-3
更新日期：2005-06-01 00:00:00
abstract：:Little is known about the bacteriophage proteins expressed immediately after infection of the host cell. Most of these early proteins are probably involved in bacteriophage-host interactions redirecting the bacterial metabolism to phage production. Interaction analysis of the first 16 phiKMV gene products (gp) identif...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-007-0967-4
更新日期：2007-01-01 00:00:00
abstract：:The genus Flavivirus (family Flaviviridae) presently comprises around 70 single-strand positive-sense RNA viruses. These replicate in a range of vertebrate and invertebrate cells and may be mosquito-borne, tick-borne or have no-known-vector. Since transmission mode correlates strongly with phylogeny, the flaviviruses ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0626-6
更新日期：2006-02-01 00:00:00
abstract：:To provide information on the mechanism of perpetuation of influenza viruses among waterfowl reservoirs in nature, virological surveillance was carried out in Alaska during their breeding season in summer from 1991 to 1994. Influenza viruses were isolated mainly from fecal samples of dabbling ducks in their nesting pl...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01322743
更新日期：1995-01-01 00:00:00
abstract：:Utilizing co-transfection of DNA from glycoprotein gB- strain of HSV1 and cloned fragments of several simian alpha-herpesviruses containing the UL26, UL27 (gB glycoprotein), and UL28 gene homologs, replication-competent recombinant viruses were produced. Genetic analysis of one HSV1/SA8 recombinant (HSV1/SgB) demonstr...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050114
更新日期：1997-01-01 00:00:00
abstract：:Acute diarrhea outbreaks caused by porcine epidemic diarrhea virus (PEDV) have been observed in various pig-breeding provinces of China since December 2010. Endemic strains of PEDV were isolated from different areas, and the complete genome sequences of 10 isolates were determined. Our objective in this study was to g...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1767-7
更新日期：2013-12-01 00:00:00
abstract：:A small unconventional, viroid-like aetiological agent might initiate Crohn's disease (CD). Electrophoresis of radiolabelled low molecular weight nucleic acids from mesenteric lymph nodes and leucocytes did not distinguish CD-specific sequences compatible with a viroid-like agent. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310895
更新日期：1986-01-01 00:00:00
abstract：:Our previous studies demonstrated that hepatitis E virus (HEV) requires the multivesicular body (MVB) pathway to release virus particles, suggesting that HEV utilizes the cellular ESCRT machinery in the cytoplasm, not at the cell surface, to be released from infected cells. In this study, we generated a murine monoclo...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1912-3
更新日期：2014-05-01 00:00:00
abstract：:Big liver and spleen disease, caused by avian hepatitis E virus, has been reported in Poland, but the prevalence of the virus has not yet been investigated. In this study, 1034 serum samples from 57 breeder broiler and laying hen flocks were screened for the presence of anti-aHEV antibodies. In a random serology study...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-4089-y
更新日期：2019-02-01 00:00:00
abstract：:Dengue virus is the most important arbovirus that affects humans, and it can establish persistent infections, especially in insect-derived cell cultures. Defective viral genomes have been implicated in the establishment and maintenance of persistent infections with several flaviviruses; however, there exists almost no...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1525-2
更新日期：2013-03-01 00:00:00
abstract：:The modes of molecular evolution of the coat protein (CP) and 3' non-coding region (NCR) were investigated in Bean yellow mosaic virus (BYMV) isolates, including a new pathotype from blue passion fruit. In phylogenetic analysis, the new pathotype did not cluster with pathotypes or host groups described previously. Int...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-009-0485-7
更新日期：2009-01-01 00:00:00
abstract：:A large sheep flock screened over a two-year period showed active spreading of Schmallenberg virus (SBV) during the summers of 2011 and 2012. Transplacental infections were observed during the two associated lambing periods (the winters of 2012 and 2013). Analysis of small (S) segment sequences of 38 SBV-positive samp...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-2787-x
更新日期：2016-05-01 00:00:00
abstract：:Many distinct polyomaviruses infecting a variety of vertebrate hosts have recently been discovered, and their complete genome sequence could often be determined. To accommodate this fast-growing diversity, the International Committee on Taxonomy of Viruses (ICTV) Polyomaviridae Study Group designed a host- and sequenc...
journal_title：Archives of virology
pub_type： 新闻
doi：10.1007/s00705-016-2794-y
更新日期：2016-06-01 00:00:00
abstract：:Virus isolate Y3V, obtained from tobacco showing leaf curl symptoms in Yunnan, China, had particles with the size and morphology typical of geminiviruses. In reactions with a set of monoclonal antibodies raised against begomoviruses, Y3V was readily differentiated from two previously studied Chinese Begomovirus isolat...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050170081
更新日期：2001-08-01 00:00:00
abstract：:Mouse cell lines (L, NIH3T3, and RMA cells) infected with the Edmonston strain of measles virus (MV) did not exhibit cytopathic effects (CPE), consistent with the finding that mice are not susceptible to MV. Northern blot analysis, however, revealed that MV genes were transcribed in infected L and NIH3T3 cells, althou...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310037
更新日期：1994-01-01 00:00:00
abstract：:To trace the possible route of introduction of porcine epidemic diarrhea virus (PEDV), the phylogenetic relationships of PEDV strains in the regions of epidemicity in the Philippines to PEDV strains that are endemic in other countries were investigated. Partial nucleotide sequences of the S1 spike gene was determined ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-2938-0
更新日期：2016-09-01 00:00:00
abstract：:Retrovirus infectivity is the result of a cooperative interaction of three structural genes, gag, pol, and env. Since the L-cell endogenous retrovirus (LCV) lacks the env gene translation product, our aim was to study the biological and molecular basis of its non-infectiousness. Fusion experiments between LCV and homo...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01315566
更新日期：1988-01-01 00:00:00
