Abstract：
:Human leukocyte antigen (HLA) alleles are associated with both the progression of chronic hepatitis C (CHC) and the sustained virological response (SVR) to antiviral therapy. HLA-A*02 is the most common HLA allele in people of European/Caucasian descent and the Chinese and Japanese population. Therefore, we investigated whether HLA-A*02 expression is associated with disease outcome in Chinese CHC patients. Three hundred thirty-one treatment-naïve CHC patients were recruited in this study. The expression of HLA-A*02 was tested by FACS and LABType SSO assays. All patients were treated weekly with pegylated interferon plus ribavirin (PEG-IFN/RBV) according to a standard protocol. Virological response was assessed by TaqMan assay at the 4th, 12th, 24th, and 48th week of therapy, and again at the 24th week post-therapy. By the end of the study, 293 CHC patients, including 144 HLA-A*02-positive patients and 149 HLA-A*02-negative patients, were evaluable for analysis. There were no statistical differences in clinicopathological parameters between HLA-A*02-positive and negative patients before antiviral therapy (P > 0.05). The HLA-A*02-positive patients had a higher rapid virological response (RVR, 74.3 % versus 62.4 %, P = 0.03) and SVR (78.5 % versus 64.4 %, P = 0.01) and a lower relapse rate (4.2 % versus 11.9 %, P = 0.03) than HLA-A*02-negative patients. Multivariable logistic regression analysis showed that HLA-A*02 expression, liver fibrosis stages journal_name journal_title authors doi subject pub_date pages issue eissn issn journal_volume pub_type
abstract：:The disease caused by Newcastle disease virus (NDV) is a severe threat to the poultry industry worldwide. Recently, NDV has been isolated in the Antarctic region. Detailed studies on the mode of evolution of NDV strains isolated worldwide are relevant for our understanding of the evolutionary history of NDV. For this ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2434-y
更新日期：2015-08-01 00:00:00
abstract：:Synthesis of the Epstein-Barr virus (EBV) associated early antigen (EA) can be induced by a variety of agents in Raji cells, a latently EBV-infected Burkitt lymphoma line. We investigated the role of lipoproteins in this EA induction system. Cell growth was not affected by lipoprotein-deficiency, but EA induction by m...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01313877
更新日期：1989-01-01 00:00:00
abstract：:Due to their natural host-range restriction to avian species, canarypox virus (CP) and fowlpox virus (FP) represent efficient and safe vaccine vectors, as they correctly express transgenes in human cells, elicit complete immune responses, and show protective efficacy in preclinical animal models. At present, no inform...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-010-0663-7
更新日期：2010-06-01 00:00:00
abstract：:The aim of this study was to evaluate the long-term effectiveness of first-line antiretroviral therapy in HIV/AIDS patients in Southeast China. A total of 450 eligible patients were selected to initiate first-line antiretroviral therapy from February 2005 through August 2009. During the study period from 2009 through ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2583-z
更新日期：2015-11-01 00:00:00
abstract：:The complete nucleotide sequence of a virus infecting ornamental hibiscus (Hibiscus sp.) in Hawaii with symptoms of green ringspots on senescing leaves was determined from double-stranded RNA isolated from symptomatic tissue. Excluding polyadenylated regions at the 3' termini, the bipartite RNA genome was 8748 and 501...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1745-0
更新日期：2013-11-01 00:00:00
abstract：:The genomes of all replication-competent retroviruses contain cis-acting elements that regulate gene expression. However, the identities of many of these elements remain to be characterized. Inserting sequences into the 3' untranslated region of a replication-competent spleen necrosis virus (SNV) vector disrupted its ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050486
更新日期：1999-01-01 00:00:00
abstract：:Structural analysis of the US-segment of a viable temperature sensitive human cytomegalovirus mutant (ts9) by the use of restriction enzymes, specific amplifications by the polymerase chain reaction and DNA sequencing, revealed deletions of open reading frames (orf) US14 and part of US15 in addition to that concerning...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01311183
更新日期：1994-01-01 00:00:00
abstract：:As a prerequisite for development of improved vaccines and diagnostic tools for control of the fish pathogen koi herpesvirus, or cyprinid herpesvirus 3 (CyHV-3), we have started to identify putative viral envelope and capsid proteins. The complete or partial CyHV-3 open reading frames ORF25, ORF65, ORF92, ORF99, ORF13...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2190-4
更新日期：2014-12-01 00:00:00
abstract：:Complete nucleotide (nt) and deduced amino acid sequences of two onion yellow dwarf virus (OYDV) isolates showing mild and severe symptoms in onion but being unable to infect garlic were determined. The genomes consisted of 10,459 and 10,461 nt (without the 3' poly(A) tail) and were 92.2 % identical. Comparison of the...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1597-z
更新日期：2013-06-01 00:00:00
abstract：:Restriction maps of cervid herpesviruses 1 and 2 which are antigenetically related to bovine herpesvirus 1, were deduced from Southern blot hybridization with HindIII restriction fragments of BHV-1 DNA as probes. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01309448
更新日期：1993-01-01 00:00:00
abstract：:During the peak outbreak (July-September 2009), a total 1886 patients were screened in eastern India, of which 139 (7.37%) and 52 (2.76%) were positive for pH1N1 and seasonal H1N1, respectively. Full-length HA1, NA, NS1 and PB1-F2 genes of representative strains were sequenced. Phylogenetic analysis of deduced amino a...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-010-0842-6
更新日期：2011-02-01 00:00:00
abstract：:The genus "Tupanvirus" is a new proposed taxon to be included in the family Mimiviridae. The two known tupanvirus isolates were isolated from soda lake and oceanic sediments samples collected in Brazil and were named "tupanvirus soda lake" and "tupanvirus deep ocean", respectively. These viruses exhibit similarities t...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-4067-4
更新日期：2019-01-01 00:00:00
abstract：:In order to determine the prevalence of multiple infections with hepatitis viruses in chronic HBsAg carriers in Naples, to assess the interaction between HBV, HDV and HCV infections and to evaluate the influence of multiple virus hepatitis infections on the clinical presentation, we studied 198 HBsAg chronic carriers ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050090
更新日期：1997-01-01 00:00:00
abstract：:Morphological, biological, serological, and molecular tests underpin the description of costus stripe mosaic virus (CoSMV) as a new member of the genus Potyvirus, family Potyviridae. Found affecting the native ornamental Costus spiralis in Brazil, the pathogen showed a severely restricted natural and experimental host...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04788-z
更新日期：2020-11-01 00:00:00
abstract：:In order to investigate the genetic diversity of porcine circovirus type 2 (PCV2), 284 clinical tissue samples were collected from different pig farms in central China from 2015 to 2017. A total of 162 tissue samples (162/284, 57.04%) were positive for PCV2 by PCR, and subsequently, the complete genome of 36 of these ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-019-04205-0
更新日期：2019-05-01 00:00:00
abstract：:The complete genome sequences of two grapevine virus L (GVL) isolates collected from the wine grape cultivar Blanc du Bois (Vitis spp.: 'Florida D 6-148'×'Cardinal') in Texas were determined. The two genome sequences (excluding the polyA tail) were each 7594 nucleotide long and 99.7% identical to each other, but they ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04682-8
更新日期：2020-08-01 00:00:00
abstract：:Bovine herpesvirus 1 (BHV-1) is a major pathogen of cattle, causing significant disease including immunosuppression in infected animals. In vitro, the surface expression of major histocompatibility complex (MHC) class I molecules, crucial for an appropriate anti-viral immune response of the host, is down-regulated by ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050070038
更新日期：2000-01-01 00:00:00
abstract：:Amino acids Lys34, His36, and Phe37 were substituted by PCR-mediated, site-directed mutagenesis for three Trp's in the AcNPV polyhedrin sequence. Phase contrast microscopy revealed refringent, amorphous polyhedra in the nuclei of infected cells. Electron microscopy confirmed a great variation in form and size of the m...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050675
更新日期：2000-01-01 00:00:00
abstract：:Using monoclonal antibodies raised against a Faba bean necrotic yellows virus (FBNYV) isolate from Egypt and a Faba bean necrotic stunt virus (FBNSV) isolate from Ethiopia, a striking serological variability among nanovirus isolates from faba bean in Morocco was revealed. To obtain a better understanding of this nanov...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-009-0548-9
更新日期：2010-01-01 00:00:00
abstract：:The genome of Duck circovirus (DuCV) is circular and 1996 nts in size. Two major open reading frames were identified, encoding the replicase (V1) and the capsid protein (C1). A stem-loop structure comprising the nonamer 5'-TATTATTAC, conserved in all circo-, nano- and geminiviruses, was found. Unique to DuCV, the regi...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-003-0181-y
更新日期：2003-12-01 00:00:00
abstract：:We investigated the transforming domain of a recently isolated feline sarcoma virus (TP1-FeSV) which encodes a fgr-related tyrosine kinase expressed as a gag-fgr fusion protein. The gag portion was removed and replication-competent expression vectors (RCAS) with inserted v-fgr sequences were established. Chicken embry...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01379113
更新日期：1994-01-01 00:00:00
abstract：:A novel Vibrio alginolyticus phage, VAP7, was isolated from seawater collected from Sanya, Hainan province, China. Whole-genome sequencing analysis revealed that phage VAP7 has a linear, double-stranded DNA genome of 144,685 bp with an average G+C content of 41.9% and a high degree of sequence similarity to Vibrio pha...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04535-4
更新日期：2020-04-01 00:00:00
abstract：:Heparin added together with murine L cell interferon inhibited the development of antiviral activity in mouse L cells. When added after interferon treatment, heparin had no effect on antiviral activity. There was also no inhibition of interferon action in L cells treated with heparin before addition of interferon. On ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314146
更新日期：1986-01-01 00:00:00
abstract：:To understand the mode of persistent infection of Seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. When 1-day-old rats were inoculated with the KI-83-262 strain, the S segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01718634
更新日期：1996-01-01 00:00:00
abstract：:We determined the complete nucleotide sequence of EDRD-1, a Japanese strain of the North American type-Porcine reproductive and respiratory syndrome virus (PRRSV), and identified a novel 117-base deletion and 108-base insertion previously reported in the nsp2 gene of the SP strain, which contains the largest genome am...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-008-0098-6
更新日期：2008-01-01 00:00:00
abstract：:A number of avian avulavirus 1 (AAvV 1) isolates have been reported from avian and non-avian hosts worldwide with varying clinical consequences. In this regard, robust surveillance coupled with advanced diagnostics, genomic analysis, and disease modelling has provided insight into the molecular epidemiology and evolut...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-019-04276-z
更新日期：2019-07-01 00:00:00
abstract：:The stools of slaughtered pigs were screened for hepatitis E virus (HEV). HEV RNA was detected in 7.3% of the samples. HEV strains were characterized as genotype 3 subtype c, a cluster previously not described in Italy. These findings provide evidence that slaughterhouse workers may be exposed to HEV infection. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-009-0544-0
更新日期：2010-01-01 00:00:00
abstract：:Spartina mottle virus (SpMV), an unassigned member of the family Potyviridae, has been known since 1980, when it was first described in England and Wales in symptomatic plants of the genus Spartina. In infected cells, flexuous particles and pinwheel inclusion bodies were found that resemble those of potyvirids. To dat...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04726-z
更新日期：2020-10-01 00:00:00
abstract：:The complete genome of O/Akesu/58 strain of foot-and-mouth disease virus (FMDV) was sequenced. The phylogenetic analysis revealed that it is not closely related to epidemic strains or previous strains compared with reference sequences (the identities of complete VP1 nucleotide sequences range from 77.5 to 84.0%). Its ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-007-1041-y
更新日期：2007-01-01 00:00:00
abstract：:Cellular uptake of fowl plague virus occurs 10-30 minutes after inoculation of chick embryo cells. The penetration of the virions is by pinocytosis (viropexis); fusion with the cellular membrane has not been observed. After pinocytosis the virions become gradually disintegrated. Budding of newly formed virions from th...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317537
更新日期：1975-01-01 00:00:00
