Abstract：
:Bovine herpesvirus 1 (BHV-1) is a major pathogen of cattle, causing significant disease including immunosuppression in infected animals. In vitro, the surface expression of major histocompatibility complex (MHC) class I molecules, crucial for an appropriate anti-viral immune response of the host, is down-regulated by BHV-1 infection. Northern blot analyses revealed that the mRNAs for MHC class I and class II molecules were significantly down-regulated in BHV-1 infected cells, starting as early as 2 h after infection. Furthermore, mRNA expression of the two house keeping genes actin and glyceraldehyde-6-phosphate dehydrogenase (GAPDH) was also repressed after infection. This BHV-1 induced effect on cellular metabolism resembled the virion host shutoff (vhs) activity of herpes simplex virus (HSV). Similar to the HSV vhs activity, the putative BHV-1 vhs activity was not abrogated in cells infected in the presence of actinomycin D (ActD) which suggested that no viral gene expression is required for the vhs function and the putative vhs protein is associated with the virion. Sequence comparison indicated a BHV-1 open reading frame having a 60% similarity to the HSV vhs sequence. This putative BHV-1 open reading frame contained the four conserved regions of the alphaherpesvirus vhs protein. Since an HSV vhs-mutant exhibited less virulence and good immunogenicity, we suggest that a BHV-1 vhs- mutant may hold promising potential as a candidate vaccine.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Hinkley S,Ambagala AP,Jones CJ,Srikumaran Sdoi
10.1007/s007050070038keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
2027-46issue
10eissn
0304-8608issn
1432-8798journal_volume
145pub_type
杂志文章abstract：:A 945 nucleotide region (bases 76-1020) of the HA1 part of the HA gene was obtained for 31 influenza viruses of H7 subtype isolated primarily from Europe, Asia and Australia over the last 20 years. These were analysed phylogenetically and compared with sequences of the same region from 23 H7 subtype viruses available ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050695
更新日期：2000-01-01 00:00:00
abstract：:Integration of bovine leukaemia virus DNA was investigated at all stages of infection in cattle. We report here the detection of integrated proviral DNA in the majority of antibody positive animals without lymphocytosis. In all but one case virus was integrated at a number of different sites. Hybridization analysis fa...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314319
更新日期：1991-01-01 00:00:00
abstract：:Four geographic variants (topotypes) of yellow fever (YF) virus from Africa and South America previously determined by RNA oligonucleotide mapping were analyzed for their structural, antigenic and virulence characteristics. The electrophoretic migration mobility and carbohydrate content of the envelope protein E chara...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310727
更新日期：1987-01-01 00:00:00
abstract：:Infections with influenza and respiratory syncytial virus (RSV) rank high among the most common human respiratory diseases worldwide. Previously, we developed a replication-incompetent influenza virus by replacing the coding sequence of the PB2 gene, which encodes one of the viral RNA polymerase subunits, with that of...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1932-z
更新日期：2014-05-01 00:00:00
abstract：:Thrips palmi transmits the tospoviruses watermelon bud necrosis (WBNV) and groundnut bud necrosis virus (GBNV) in persistent propagative way. Little is known about the T. palmi-WBNV and -GBNV relationship. In this study, we report the effects of WBNV and GBNV infection on the life history traits of T. palmi. Both WBNV...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-019-04381-z
更新日期：2019-11-01 00:00:00
abstract：:The rate of evolution of the human papillomavirus 16 (HPV16) genome is low. However, the ability of the E6 oncoprotein to interact with distinct p53 variants causes selective pressure on the E6 gene. In addition, intratypic recombination events in the HPV16 E6 and E7 genes have been characterized as extraordinary phen...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1555-9
更新日期：2013-04-01 00:00:00
abstract：:The interaction between two different bovine respiratory syncytial virus (BRSV) strains and bovine alveolar macrophages (BAMs) was studied in vitro. Bovine respiratory syncytial virus replicated minimally in BAMs and most of the virus produced remained cell-associated. Approximately 1 out of 1,000 BAMs produced infect...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01322681
更新日期：1995-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01316895
更新日期：1993-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-019-04257-2
更新日期：2019-07-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01313885
更新日期：1989-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-004-0323-x
更新日期：2004-09-01 00:00:00
abstract：:Bohle iridovirus (BIV) belongs to the genus Ranavirus, of which Frog virus 3 (FV-3) is the type species. We are developing BIV as a recombinant viral delivery vector, and as a first step we located specific BIV promoter sequences to drive foreign gene expression in the recombinant virus. By comparison with FV-3 sequen...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0532-y
更新日期：2005-09-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310491
更新日期：1991-01-01 00:00:00
abstract：:In February 2019, following the annual taxon ratification vote, the order Bunyavirales was amended by creation of two new families, four new subfamilies, 11 new genera and 77 new species, merging of two species, and deletion of one species. This article presents the updated taxonomy of the order Bunyavirales now accep...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-019-04253-6
更新日期：2019-07-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01718159
更新日期：1996-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01322532
更新日期：1995-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310741
更新日期：1987-01-01 00:00:00
abstract：:Thirty-seven clinical isolates of coxsackievirus (CV) serotypes B-1, B-3, B-4, and B-5 were inoculated into male SJL mice. Twelve strains resulted in minor abnormalities of glucose metabolism in one or more of six infected mice (Tables 1 and 2). Sequential infection of male SJL mice with CVB-3, CVB-4, and CVB-5 result...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01309826
更新日期：1985-01-01 00:00:00
abstract：:The duration of infection with rat virus (RV), an autonomous rodent parvovirus, was examined at multiple intervals over 6 months in rats inoculated by the oronasal route at 2 days of age or 4 weeks of age and individually housed after weaning to prevent cross-infection. Infectious virus was recovered by explant cultur...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310765
更新日期：1991-01-01 00:00:00
abstract：:Four distinct double-stranded (ds) RNA bands were extracted from leaves of Raphanus sativus-root cv. Yidianhong [corrected] with yellowing at the leaf edge in China. Purified viral particles of 28-30 nm in diameter contained dsRNA segments with the same number and mobility as these extracted directly from radish leave...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0685-8
更新日期：2006-05-01 00:00:00
abstract：:In the present study, the detection of a pantropic canine coronavirus (CCoV) strain in a dog with lethal diarrhoea is reported. RT-PCR and real-time RT-PCR assays were used for the detection, characterization and quantitation of CCoV. Sequence and phylogenetic analysis of the CCoV NA/09 revealed a high degree of seque...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-011-1141-6
更新日期：2012-01-01 00:00:00
abstract：:Chilo iridescent virus (CIV; the type strain of the genus Iridovirus) replicates productively in larvae of the boll weevil, Anthonomus grandis. This study focuses on characterizing productive infections of a boll weevil cell line, BRL-AG-3A (AG3A), starting with CIV reared in the waxworm, Galleria mellonella. We show ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1417-5
更新日期：2012-11-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-017-3509-8
更新日期：2017-11-01 00:00:00
abstract：:Tissues of the central nervous system (CNS) of cynomolgus monkeys were examined by electron microscopy after intraspinal inoculation of enterovirus 71 (E71). A characteristic finding was the appearance of numerous membrane-bound vesicles (Mbvs) in affected motoneurons. Similar Mbvs were also present in E71-infected cy...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314120
更新日期：1985-01-01 00:00:00
abstract：:Expression of the entire open reading frame of hepatitis A virus was achieved in a vaccinia virus/T7/EMCV hybrid system. The expressed antigens were characterized as particles with buoyant densities and sedimentation coefficients typical of empty capsids and pentamers of HAV. This was further confirmed by electron mic...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310029
更新日期：1994-01-01 00:00:00
abstract：:Neutralizing activity against dengue virus types 1--4 was observed in milk samples from 5 non-immune and 29 dengue immune women. Anti-dengue activity in milk and colostrum was found only in the lipid component. The inhibitory activity is directed against the virus and not cell surfaces. When immunoglobulin types IgM,I...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01315587
更新日期：1975-01-01 00:00:00
abstract：:Simultaneous infection of primary rabbit kidney cells with HSV type 1 TK+ and a TK- strain results in a mutual influence of both viruses on the induction of thymidine kinase (TK). TK+ virus has an enhancing and TK- virus a depressing effect on TK induction by a superinfecting TK+ virus. The enzyme induction depends on...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317531
更新日期：1975-01-01 00:00:00
abstract：:The Pasteur strain of fixed rabies virus was adapted to primary cell cultures of Japanese quail embryos and designated as MNIIVP-74. In the course of adaptation the virus pathogenicity for rabbits by the intracerebral route decreased considerably and the pathogenicity for rabbits and adult white mice by extraneural ro...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01320592
更新日期：1979-01-01 00:00:00
abstract：:Chilo iridescent virus (CIV; IIV-6) is the type member of the genus Iridovirus (family Iridoviridae, large icosahedral cytoplasmic DNA viruses). CIV induces death and deformity in the cotton boll weevil, Anthonomus grandis, replicates productively in larvae of the cotton boll weevil, and significantly reduces laborato...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-007-0945-x
更新日期：2007-01-01 00:00:00
abstract：:The EDS adenovirus produced either in the allantoic cavity of embryonated duck eggs (A0 virus) or in chicken embryo liver cell cultures (TC0 virus) were comparatively studied by gradient ultracentrifugation in CsCl. The A0 viral particles banded at densities of 1.36 and 1.31 g/ml, whereas, the TC0 viral particle were ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314574
更新日期：1981-01-01 00:00:00
