Comparative immunochemical and biological analysis of African and South American yellow fever viruses.

Abstract:

:Four geographic variants (topotypes) of yellow fever (YF) virus from Africa and South America previously determined by RNA oligonucleotide mapping were analyzed for their structural, antigenic and virulence characteristics. The electrophoretic migration mobility and carbohydrate content of the envelope protein E characterized YF virus strains of South America. The NS 1 protein of South American and Central African YF virus strains was not precipitated by anti-NS 1 monoclonal antibodies (MAB) that precipitated NS 1 of West African strains. No distinction could be made among the YF virus strains on the basis of the neutralizing capacity of available MAB. South American, but not African YF virus strains were virulent for 8-day-old mice upon intraperitoneal inoculation. The results permitted characterization of topotypes of Central Africa and South America but failed to differentiate YF strains from West Africa.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Deubel V,Schlesinger JJ,Digoutte JP,Girard M

doi

10.1007/BF01310727

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

331-8

issue

3-4

eissn

0304-8608

issn

1432-8798

journal_volume

94

pub_type

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