Abstract：
:To provide information on the mechanism of attenuation of a Newcastle disease vaccine strain, TCND, we compared it with the parental virulent strain California 11,914 (CAL) biologically and genetically. It was found that TCND bore the fusion protein of virulent type, consisting of a pair of dibasic amino acid residues at the cleavage site and was a temperature sensitive (ts) mutant restricted to grow at 41.5 degrees C. Revertants were obtained by prolonged incubation of chicken embryos inoculated with TCND at the nonpermissive temperature. In cultured cells, viral gene transcription and protein synthesis of TCND occurred similarly to those of CAL and the revertants at 41.5 degrees C. Hemadsorption and immunofluorescence assays revealed that cell surface expression of functional hemagglutinin-neuraminidase (HN) of TCND at 41.5 degrees C was lower than that at 35 degrees C. The revertants exhibited lower activity in fusion assay than CAL and recovered virulence to chicken only in part. The results indicate that the ts mutation of TCND in association with the defect of HN glycoprotein transport is a mechanism of the attenuation, and in addition, some other factors such as fusion activity should be involved in the loss of virulence of CAL to chickens.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Takakuwa H,Ito T,Takada A,Okazaki K,Kida Hdoi
10.1007/s007050050361subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1129-43issue
6eissn
0304-8608issn
1432-8798journal_volume
143pub_type
杂志文章abstract：:During the course of hominoid evolution, a new transcript variant of the GSDML (gasdermin-like protein) gene was formed by the integration of the antisense-oriented HERV-H (human endogenous retrovirus) LTR (long terminal repeat) element. To investigate regions that are critical for transcriptional regulation of the GS...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-008-0105-y
更新日期：2008-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04834-w
更新日期：2021-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01309370
更新日期：1984-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00705-012-1414-8
更新日期：2013-03-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-010-0628-x
更新日期：2010-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00705-012-1495-4
更新日期：2013-02-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1417-5
更新日期：2012-11-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1731-6
更新日期：2014-03-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01322675
更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00705-016-3024-3
更新日期：2016-12-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01322532
更新日期：1995-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s00705-013-1767-7
更新日期：2013-12-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2017-08-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s705-002-8327-7
更新日期：2002-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01320765
更新日期：1980-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01322666
更新日期：1995-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01718424
更新日期：1995-01-01 00:00:00
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更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-06-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
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更新日期：1981-01-01 00:00:00
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更新日期：1999-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-08-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050100
更新日期：1997-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01321010
更新日期：1988-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01318024
更新日期：1976-01-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
