Abstract：
:The use of the complete DNA sequence for the Marek's disease virus (MDV) serotype 1 vaccine strain CVI988 Rispens in comparative genomic studies with virulent strains of MDV has revealed the presence of a number of insertions, deletions and single-nucleotide polymorphisms. In this study, we investigated a SNP in the H/ACA box of the viral RNA subunit of telomerase (vTR). We sequenced vTR from four different batches of CVI988 vaccine originating from a single commercial company. The A-to-G mutation defining the SNP in the H/ACA box of CVI988 vTR was present in only some of the batches. Thus, although this mutation affects CVI988 vTR function, it is not shared by all CVI988 isolates and may be a stochastic rather than causative event in CVI988 attenuation.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Debba-Pavard M,Le Galludec H,Dambrine G,Rasschaert Ddoi
10.1007/s00705-008-0152-4subject
Has Abstractpub_date
2008-01-01 00:00:00pages
1563-8issue
8eissn
0304-8608issn
1432-8798journal_volume
153pub_type
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