Bovine respiratory syncytial virus replicates minimally in bovine alveolar macrophages.

Abstract:

:The interaction between two different bovine respiratory syncytial virus (BRSV) strains and bovine alveolar macrophages (BAMs) was studied in vitro. Bovine respiratory syncytial virus replicated minimally in BAMs and most of the virus produced remained cell-associated. Approximately 1 out of 1,000 BAMs produced infectious virus, a number that further declined during the 7 days of culture. In contrast, BAMs exposed to bovine parainfluenza 3 virus (PI3V) produced high amounts of infectious virus. The number of BAMs that contained BRSV antigen depended on the antigen load of the inoculum and not on the infectivity of the virus. Antibody mediated enhancement of infection was not detected. It is concluded that bovine alveolar macrophages exhibit a high intrinsic resistance to BRSV, but not to PI3V.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Schrijver RS,Kramps JA,Middel WG,Langedijk JP,van Oirschot JT

doi

10.1007/BF01322681

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

1905-17

issue

11

eissn

0304-8608

issn

1432-8798

journal_volume

140

pub_type

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