Abstract：
:Mice are protected against lethal intraperitoneal and intravenous infection by encephalomyocarditis virus and Semliki Forest virus by sequential treatment with poly I followed by either polyC or poly5-hydroxyC without production of interferon when the treatments are 4 or more hours apart and by the intraperitoneal or intravenous routes. Maximum protection occurs around 4 hours before infection and is still significant 20 hours after infection. Treatments with combinations of other homoribopolynucleotides were not found to be anti-viral. Protection by sequential polyI, polyC treatment of mice is relatively short-lived and does not 'hypo-reactivate' the protective effect of polyI:C and shows approximately half the protective effect of polyI:C. The toxicity of sequential polyI, polyC treatment is lower than that of polyI:C particularly if poly5-hydroxyC is substituted for polyC. Silica treatment of mice indicates that stationary macrophages are required for protection by polyI followed by polyC but an effect on humoral or cell mediated immune responses does not appear to be involved. The effect appears to be a synergism between the protection conferred by polyI or polyC alone.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Stebbing N,Grantham CAdoi
10.1007/BF01318024subject
Has Abstractpub_date
1976-01-01 00:00:00pages
199-215issue
3eissn
0304-8608issn
1432-8798journal_volume
51pub_type
杂志文章abstract：:Cassava mosaic geminiviruses (CMGs) are implicated in cassava mosaic disease (CMD), the main constraint to cassava production in Africa. Here, we report the complete nucleotide sequences of the DNA-A and DNA-B of a newly characterized CMG found infecting cassava in Madagascar, for which we propose the tentative name c...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-012-1399-3
更新日期：2012-10-01 00:00:00
abstract：:In order to prepare H5N1 influenza virus vaccine, the hemagglutinins (HAs) of 14 H5 virus isolates from water birds in Asia were antigenically and genetically analyzed. Phylogenetic analysis of the H5 HA genes revealed that 13 isolates belong to Eurasian and the other one to North American lineages. Each of the deduce...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-008-0226-3
更新日期：2008-01-01 00:00:00
abstract：:In order to investigate the genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV) strains currently circulating in the Republic of Ireland (ROI), the ORF5 gene from 17 field strains originating from four vaccinating commercial herds was sequenced and phylogenetically analysed. High genetic v...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04710-7
更新日期：2020-09-01 00:00:00
abstract：:Hepatitis B virus (HBV) infection has a major effect on health care systems, with about one-third of the world's population currently infected with the virus. There is an effective vaccine against HBV, which contains a recombinant "surface antigen" produced in an expression vector. Vaccination has proved to be success...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-008-0206-7
更新日期：2008-01-01 00:00:00
abstract：:Sequence analysis of a 6.4 kb DNA region from the Spodoptera littoralis multinucleocapsid nucleopolyhedrovirus (SpliNPV) revealed a large open reading frame (ORF) encoding a predicted polypeptide of 998 amino acid (aa) residues with a molecular mass of 114.93 kDa, located between 47.2-52.3 m.u. on the SpliNPV genome. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050170177
更新日期：2001-01-01 00:00:00
abstract：:In this study, we describe a novel mycovirus isolated from Trichoderma asperellum, which was designated Trichoderma asperellum dsRNA Virus 1 (TaRV1). The sequence analysis revealed that TaRV1 has two discontinuous open reading frames (ORF), ORF1 and ORF2. A hypothetical protein and an RNA-dependent RNA polymerase are ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-3988-2
更新日期：2018-12-01 00:00:00
abstract：:Human polymorphonuclear leukocytes (PMNL) incubated with influenza virus, A/USSR/90/77 (H1N1) or its hemagglutinin produced a significant increase in their PKC activity when compared with untreated PMNL. The activated kinase translocated from cytosol to cellular membrane. The calcium-dependent enzyme activity was inhi...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s007050050439
更新日期：1998-01-01 00:00:00
abstract：:Sugarcane streak mosaic virus (SCSMV), an economically important causal agent of mosaic disease of sugarcane, is a member of the newly created genus Poacevirus in the family Potyviridae. In this study, we report the molecular characterization of three new SCSMV isolates from China (YN-YZ211 and HN-YZ49) and Myanmar (M...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-2810-2
更新日期：2016-06-01 00:00:00
abstract：:During aetiological study of diseased red clover (Trifolium pratense L.) using high throughput sequencing, a novel virus with a 10 kb genome divided into two segments was discovered. The virus, tentatively named red clover associated varicosavirus (RCaVV), is phylogenetically related to classifiable members of the gen...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-3838-2
更新日期：2018-08-01 00:00:00
abstract：:Cross hemagglutination inhibition (HI) and neuraminidase inhibition (NI) tests demonstrated strong antigenic relationship between A/Swine/Wisconsin/1/73 (SW/73) and A/Swine/Shope/15/31 (SW/31) influenza viruses. An eigthyone fold purification of virus was achieved by adsorption and elution followed by differential ult...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317967
更新日期：1975-01-01 00:00:00
abstract：:A pivotal step in the development of a consistent nomenclature for virus classification was the introduction of the virus species concept by the International Committee on Taxonomy of Viruses (ICTV) in 1991. Yet, almost two decades later, many virologists still are unable to differentiate between virus species and act...
journal_title：Archives of virology
pub_type： 杂志文章,评审
doi：10.1007/s00705-010-0600-9
更新日期：2010-04-01 00:00:00
abstract：:Eco RI fragment G of equine herpesvirus 4 strain 405/76 (EHV 4.405/76) is located at the left end of the unique short region close to or extending into the internal repeat region of the prototypic arrangement of the genome. The nucleotide sequence of two subclones designated HS and G 19, contiguous within Eco RI fragm...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01309795
更新日期：1993-01-01 00:00:00
abstract：:By means of indirect immunofluorescence assay (IFA) using natural swine immune serum and hyperimmune serum from rabbits infected with porcine circovirus (PCV), a PCV antigen was detected present prior to the onset of viral and cellular DNA synthesis in nucleoli of cells of synchronized and growth stimulated infected P...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01384343
更新日期：1995-01-01 00:00:00
abstract：:Three sets of primers to detect foot-and-mouth disease virus (FMDV) using multiplex RT-PCR were designed based on several reference nucleotide sequences, and their reaction conditions were determined. By testing ten-fold serial dilutions of FMDV, the sensitivity of multiplex RT-PCR is 100 times higher than conventiona...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-007-1082-y
更新日期：2008-01-01 00:00:00
abstract：:Mouse hepatitis virus 3 (MHV-3) is highly hepatotropic in sensitive mice. Temperature-sensitive mutants (ts mutants) induced by N-methyl-N'-nitrosoguanidine and 5-fluorouracil were isolated. Twelve mutants which were able to induce the formation of syncytia at 33 degrees C but not at the restrictive temperature (39.5 ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01487679
更新日期：1988-01-01 00:00:00
abstract：:Two group A rotaviruses (ISU-64 and ISU-65) with subgroup I antigen were isolated from pigs with diarrhea and were shown by two-way neutralization tests to be two new serotypes of porcine rotavirus. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310917
更新日期：1988-01-01 00:00:00
abstract：:Complete genome sequences of two new isolates of narcissus late season yellows virus (NLSYV) from Australia were compared with the other NLSYV genome from China and with two complete genomes of isolates designated narcissus yellow stripe virus (NYSV), one from Australia and the other from China. On the basis of sympto...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1969-z
更新日期：2014-06-01 00:00:00
abstract：:Ultraviolet (UV) inactivation and photoreactivation of Anacystis nidulans and cyanophage AS-1 was studied at different wavelengths. UV inactivation of free phage particles and one and two hour host-phage complexes (intracellular phages) were exponential. UV resistance of plaque forming units was attained at the latter...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01317413
更新日期：1979-01-01 00:00:00
abstract：:We demonstrate for the first time that a putative third member of the genus Anellovirus (TTV/TTMV) is present in the blood of healthy persons (20% prevalence), and also in their PBMNC and saliva samples. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0660-4
更新日期：2006-02-01 00:00:00
abstract：:The duration of infection with rat virus (RV), an autonomous rodent parvovirus, was examined at multiple intervals over 6 months in rats inoculated by the oronasal route at 2 days of age or 4 weeks of age and individually housed after weaning to prevent cross-infection. Infectious virus was recovered by explant cultur...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310765
更新日期：1991-01-01 00:00:00
abstract：:Studies on rotavirus non-structural proteins have been hampered in the past by difficulties in obtaining monospecific reagents. To make such reagents available, we have expressed in the baculovirus system NSP2 and NSP3 (formerly called NS35 and NS34, respectively) of the bovine rotavirus RF and produced hybridomas aga...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01309746
更新日期：1993-01-01 00:00:00
abstract：:Cowpea and broad bean plants showing severe stunting and leaf rolling symptoms were observed in Hefei city, Anhui province, China, in 2014. Symptomatic plants from both species were shown to be infected with milk vetch dwarf virus (MDV) by PCR. The complete genomes of MDV isolates from cowpea and broad bean were seque...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-017-3348-7
更新日期：2017-08-01 00:00:00
abstract：:Echovirus 33 (E33) has been infrequently detected and is less frequently associated with clinical diseases when compared with other types of enteroviruses (EVs) in China. An outbreak of E33 was identified in four schools in Hunan Province, China, in June 2013. For laboratory diagnosis, throat swabs and/or serum specim...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2059-6
更新日期：2014-09-01 00:00:00
abstract：:We detected a novel feline stool-associated circular DNA virus (FeSCV) in fecal samples from cats with diarrhea using consensus primers matching those of circovirus and cyclovirus. FeSCV is a circular DNA virus containing a genome with a total length of 2,046 nt encoding 2 open reading frames. Phylogenetic analyses in...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-4020-6
更新日期：2018-12-01 00:00:00
abstract：:Oncogene-containing retroviruses are generated by recombination events between viral and cellular sequences, a phenomenon called "oncogene capture". The captured cellular genes, referred to as "v-onc" genes, then acquire new oncogenic properties. We report a novel feline leukemia virus (FeLV), designated "FeLV-AKT", t...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-3192-1
更新日期：2017-04-01 00:00:00
abstract：:Sixteen patients with symptoms typical for Ockelbo disease (rash, arthralgia, fever) were enrolled in a 2 1/2 year study, during which clinical symptoms were recorded and ELISA was employed to study specific IgM, IgG and IgG subclass development. Initially, all patients presented with rash and arthralgia, and five pat...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01379107
更新日期：1994-01-01 00:00:00
abstract：:A regional epidemic of aseptic meningitis caused by echovirus 30 (E30) occurred in Hokkaido, Japan, during the period of August-December 2017. To investigate their phylogenetic relationship to other human enteroviruses, we determined the complete genomic nucleotide sequences of isolates from this outbreak. Phylogeneti...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-019-04484-7
更新日期：2020-02-01 00:00:00
abstract：:The resistance of transgenic Nicotiana benthamiana plants encoding wild type, truncated and point mutants of the tobacco etch virus (TEV) coat protein (CP) was analyzed. After R1 plants from 45 transgenic lines were challenged with TEV, six percent of the lines exhibited high resistance, 38% exhibited low resistance, ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0577-y
更新日期：2005-12-01 00:00:00
abstract：:Immunofluorescence assay using monospecific and monoclonal antibodies to the 65 K major protein of human cytomegalovirus (HCMV) was carried out to monitor the expression of this protein in infected cells. Regardless of differences in the reactivity of the monoclonal antibodies, as determined by immunoblotting and immu...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314653
更新日期：1988-01-01 00:00:00
abstract：:Hybridomas secreting monoclonal antibodies against herpes simplex virus (HSV) DNA binding proteins (DBP) have been produced. Five HSV DBP have been characterized according to molecular weight, affinity for DNA, kinetic class and localization within the infected cell. By preparing an immunoadsorbent column from antibod...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01314300
更新日期：1984-01-01 00:00:00
