AKT capture by feline leukemia virus.

Abstract:

:Oncogene-containing retroviruses are generated by recombination events between viral and cellular sequences, a phenomenon called "oncogene capture". The captured cellular genes, referred to as "v-onc" genes, then acquire new oncogenic properties. We report a novel feline leukemia virus (FeLV), designated "FeLV-AKT", that has captured feline c-AKT1 in feline lymphoma. FeLV-AKT contains a gag-AKT fusion gene that encodes the myristoylated Gag matrix protein and the kinase domain of feline c-AKT1, but not its pleckstrin homology domain. Therefore, it differs structurally from the v-Akt gene of murine retrovirus AKT8. AKT may be involved in the mechanisms underlying malignant diseases in cats.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Kawamura M,Umehara D,Odahara Y,Miyake A,Ngo MH,Ohsato Y,Hisasue M,Nakaya MA,Watanabe S,Nishigaki K

doi

10.1007/s00705-016-3192-1

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

1031-1036

issue

4

eissn

0304-8608

issn

1432-8798

pii

10.1007/s00705-016-3192-1

journal_volume

162

pub_type

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