Abstract:
:Oncogene-containing retroviruses are generated by recombination events between viral and cellular sequences, a phenomenon called "oncogene capture". The captured cellular genes, referred to as "v-onc" genes, then acquire new oncogenic properties. We report a novel feline leukemia virus (FeLV), designated "FeLV-AKT", that has captured feline c-AKT1 in feline lymphoma. FeLV-AKT contains a gag-AKT fusion gene that encodes the myristoylated Gag matrix protein and the kinase domain of feline c-AKT1, but not its pleckstrin homology domain. Therefore, it differs structurally from the v-Akt gene of murine retrovirus AKT8. AKT may be involved in the mechanisms underlying malignant diseases in cats.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Kawamura M,Umehara D,Odahara Y,Miyake A,Ngo MH,Ohsato Y,Hisasue M,Nakaya MA,Watanabe S,Nishigaki Kdoi
10.1007/s00705-016-3192-1subject
Has Abstractpub_date
2017-04-01 00:00:00pages
1031-1036issue
4eissn
0304-8608issn
1432-8798pii
10.1007/s00705-016-3192-1journal_volume
162pub_type
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