The characterization and purification of DNA binding proteins present within herpes simplex virus infected cells using monoclonal antibodies.

Abstract:

:Hybridomas secreting monoclonal antibodies against herpes simplex virus (HSV) DNA binding proteins (DBP) have been produced. Five HSV DBP have been characterized according to molecular weight, affinity for DNA, kinetic class and localization within the infected cell. By preparing an immunoadsorbent column from antibody TI8, its specific DBP was purified to apparent homogeneity. The purified DBP retained the ability to bind to DNA.

journal_name

Arch Virol

journal_title

Archives of virology

authors

la Thangue NB,Chan WL

doi

10.1007/BF01314300

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

13-33

issue

1-2

eissn

0304-8608

issn

1432-8798

journal_volume

79

pub_type

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