Variations in glycosylation of the influenza virus hemagglutinin of subtype H7. Brief report.

Abstract:

:The numbers of the carbohydrate side chains have been analyzed on a series of subtype 7 hemagglutinins of influenza A virus. The procedure employed involves growth of the virus in the presence of the trimming inhibitor N-methyl-1-desoxynojirimycin followed by controlled removal of the resulting mannose-rich oligosaccharides with endo-N-acetylglucosaminidase H. By comparative analysis with virus grown in the absence of the inhibitor oligomannosidic side chains can be discriminated from complex ones. The results show that all H7 hemagglutinins have a complex and an oligomannosidic side chain on HA2, whereas the oligosaccharides of HA1 vary in number.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Klenk HD,Schwarz RT

doi

10.1007/BF01314433

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

359-63

issue

3-4

eissn

0304-8608

issn

1432-8798

journal_volume

97

pub_type

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