Abstract：
:We studied the kinetics of localisation of matrix (M) protein of Human respiratory syncytial virus (RSV) in infected cells. M protein was detected in the nucleus early in infection, by confocal microscopy and by immunoblotting of nuclear fractions. We next tested the possibility that M protein may be involved in inhibition of host cell transcription. Nuclear extracts from RSV infected cells had less transcriptional activity in vitro when compared to nuclear extracts from mock infected cells. In addition, nuclear extracts from RSV infected cells inhibited the transcriptional activity of nuclear extracts from mock infected cells, suggesting that an inhibitory activity was transferred with nuclear extracts from RSV infected cells. Our data suggest that M protein may play a role early in the infection by inhibiting host cell transcription.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Ghildyal R,Baulch-Brown C,Mills J,Meanger Jdoi
10.1007/s00705-003-0112-ykeywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
1419-29issue
7eissn
0304-8608issn
1432-8798journal_volume
148pub_type
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journal_title：Archives of virology
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journal_title：Archives of virology
pub_type： 杂志文章
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journal_title：Archives of virology
pub_type： 杂志文章
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journal_title：Archives of virology
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更新日期：2010-11-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-007-0958-5
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pub_type： 杂志文章
doi：10.1007/BF02175599
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pub_type： 杂志文章
doi：10.1007/s007050050394
更新日期：1998-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s007050050600
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journal_title：Archives of virology
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doi：10.1007/s007050050640
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journal_title：Archives of virology
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journal_title：Archives of virology
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journal_title：Archives of virology
pub_type： 杂志文章
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-002-0930-3
更新日期：2003-03-01 00:00:00
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journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-017-3627-3
更新日期：2018-02-01 00:00:00
