Abstract:
:Synthesis of the Epstein-Barr virus (EBV) associated early antigen (EA) can be induced by a variety of agents in Raji cells, a latently EBV-infected Burkitt lymphoma line. We investigated the role of lipoproteins in this EA induction system. Cell growth was not affected by lipoprotein-deficiency, but EA induction by most combinations of the inducers TPA (tetradecanoyl-phorbol-acetate), IdU (iododeoxyuridine), n-BA (n-butyric acid), anti-IgM and EA inducing factor (EIF), was greatly reduced. Only the inducer combination TPA/n-BA was completely independent of the presence of lipoproteins, indicating a different induction pathway. Removing the lipid moieties of the culturing serum did not result in reduced EA induction. Thus, the lowered EA inducibility in lipoprotein-deficiency is due to the absence of the protein moiety (apolipoprotein). Addition of HDL or VLDL partially reconstituted the original EA inducibility, whereas LDL had no effect. Lipoproteins were particularly important during the first 4 hours of induction, the phase where inducers may act on cell membrane structures (e.g., receptors). But lipoproteins were also required throughout the incubation period, even in a late and inducer independent phase.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Simon M,Melzner I,Bültmann Bdoi
10.1007/BF01313877subject
Has Abstractpub_date
1989-01-01 00:00:00pages
45-53issue
1-2eissn
0304-8608issn
1432-8798journal_volume
107pub_type
杂志文章abstract::Sixteen patients with symptoms typical for Ockelbo disease (rash, arthralgia, fever) were enrolled in a 2 1/2 year study, during which clinical symptoms were recorded and ELISA was employed to study specific IgM, IgG and IgG subclass development. Initially, all patients presented with rash and arthralgia, and five pat...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01379107
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journal_title:Archives of virology
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journal_title:Archives of virology
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doi:10.1007/s00705-015-2646-1
更新日期:2016-01-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-005-0685-8
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journal_title:Archives of virology
pub_type: 杂志文章
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journal_title:Archives of virology
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doi:10.1007/s00705-018-04131-7
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journal_title:Archives of virology
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01318024
更新日期:1976-01-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01314420
更新日期:1987-01-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-009-0397-6
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01323161
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-012-1225-y
更新日期:2012-05-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-016-2759-1
更新日期:2016-05-01 00:00:00
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journal_title:Archives of virology
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journal_title:Archives of virology
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journal_title:Archives of virology
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journal_title:Archives of virology
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journal_title:Archives of virology
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01311326
更新日期:1983-01-01 00:00:00
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journal_title:Archives of virology
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journal_title:Archives of virology
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journal_title:Archives of virology
pub_type: 杂志文章
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01718291
更新日期:1996-01-01 00:00:00
abstract::Outbreaks of swine influenza were first observed in Japan in 1978. A number of influenza viruses were isolated from diseased swine. Almost all viruses isolated were swine influenza virus (Hsw 1 N1) but two viruses isolated from the nasal swabs of swine showing clinical signs of influenza in the Kanagawa prefecture wer...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01314741
更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00705-012-1480-y
更新日期:2013-01-01 00:00:00