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Passive immunization of mice with monoclonal antibodies raised against tick-borne encephalitis virus. Brief report.

Abstract：

:Adult Balb/c mice were passively immunized with monoclonal antibodies (100 micrograms/mouse) raised against tick-borne encephalitis (TBE) virus then challenged 24 hours later s.c. with 10 LD50 of TBE virus (Nëudorfl isolate). None of the mice showed evidence of premature death although all except one of the monoclonal antibodies tested are capable of enhancing the infectivity of TBE virus in the Fc receptor-bearing mouse macrophage-like cell line P 388 D 1. The ability of monoclonal antibodies to neutralize TBE virus in vitro, and to fix complement was examined, and of these properties only a single monoclonal antibody, which was able to neutralize virus, was also able to protect mice against virus challenge.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Phillpotts RJ,Stephenson JR,Porterfield JS

doi

10.1007/BF01310983

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

295-301

issue

3-4

eissn

0304-8608

issn

1432-8798

journal_volume

93

pub_type

杂志文章

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