Epidemiological trends and virological traits of hepatitis B virus infection in pregnant women and neonates.

Abstract:

:In infants, hepatitis B virus (HBV) infections are mainly acquired by mother-to-child transmission (MTCT). Current tests for the presence of HBV markers at birth can neither confirm nor exclude MTCT. The aim of this study was to find an early diagnostic marker of HBV MTCT. From 2011 to 2016, we studied a total of 5999 pregnant women who gave birth at our hospital in Shenzhen City, China. HBsAg-positive mothers and their offspring (n=386 pairs) were tested at birth for HBV markers, and 207 infants were followed up at 7-12 months after birth. The HBsAg-seropositive rate of the pregnant women was 12.5%. Additionally, 28.0%, 36.0%, 98.5% and 6.6% of umbilical cord (UC) blood samples of neonates were found to be positive for HBsAg, HBeAg, anti-HBc and HBV-DNA, respectively, whereas for neonatal femoral venous (FV) blood, the percentages were 16.2%, 38.0%, 98.8% and 2.6%, respectively. Mothers with high HBV DNA loads and those who were HBeAg positive were the most likely to have HBV-positive offspring. Immunoprophylaxis failed in five infants: the difference in median HBV DNA titer between UC blood from infants with and without HBV MTCT was statistically significant, and there was no significant difference in HBV DNA titer between UC blood and in peripheral blood of infants with HBV MTCT. In conclusion, we found that HBeAg positivity and high HBV loads are strong risk factors for MTCT of HBV and that the HBV DNA titer in the UC is a good predictor for HBV MTCT.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Peng TT,Cai QE,Yang M,Chen SP,Chen F,Wang M,Peng L,Wong G,Shen CG,Cheng WB,Liu SY,Peng YB,Peng JH,Chen CM,Yang LQ,Tang YM,Xu ZX,Liu YX

doi

10.1007/s00705-019-04190-4

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

1335-1341

issue

5

eissn

0304-8608

issn

1432-8798

pii

10.1007/s00705-019-04190-4

journal_volume

164

pub_type

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