Abstract:
:In infants, hepatitis B virus (HBV) infections are mainly acquired by mother-to-child transmission (MTCT). Current tests for the presence of HBV markers at birth can neither confirm nor exclude MTCT. The aim of this study was to find an early diagnostic marker of HBV MTCT. From 2011 to 2016, we studied a total of 5999 pregnant women who gave birth at our hospital in Shenzhen City, China. HBsAg-positive mothers and their offspring (n=386 pairs) were tested at birth for HBV markers, and 207 infants were followed up at 7-12 months after birth. The HBsAg-seropositive rate of the pregnant women was 12.5%. Additionally, 28.0%, 36.0%, 98.5% and 6.6% of umbilical cord (UC) blood samples of neonates were found to be positive for HBsAg, HBeAg, anti-HBc and HBV-DNA, respectively, whereas for neonatal femoral venous (FV) blood, the percentages were 16.2%, 38.0%, 98.8% and 2.6%, respectively. Mothers with high HBV DNA loads and those who were HBeAg positive were the most likely to have HBV-positive offspring. Immunoprophylaxis failed in five infants: the difference in median HBV DNA titer between UC blood from infants with and without HBV MTCT was statistically significant, and there was no significant difference in HBV DNA titer between UC blood and in peripheral blood of infants with HBV MTCT. In conclusion, we found that HBeAg positivity and high HBV loads are strong risk factors for MTCT of HBV and that the HBV DNA titer in the UC is a good predictor for HBV MTCT.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Peng TT,Cai QE,Yang M,Chen SP,Chen F,Wang M,Peng L,Wong G,Shen CG,Cheng WB,Liu SY,Peng YB,Peng JH,Chen CM,Yang LQ,Tang YM,Xu ZX,Liu YXdoi
10.1007/s00705-019-04190-4subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1335-1341issue
5eissn
0304-8608issn
1432-8798pii
10.1007/s00705-019-04190-4journal_volume
164pub_type
杂志文章abstract::Konjak mosaic virus (KoMV) belongs to the genus Potyvirus, family Potyviridae. The complete nucleotide sequence of KoMV F isolate (KoMV F) was determined. The genome is 9,544 nucleotides long excluding the 3' terminal poly A tail and encodes a typical potyviral 350-kDa polyprotein of 3,087 amino acids. Phylogenetic an...
journal_title:Archives of virology
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journal_title:Archives of virology
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doi:10.1007/s007050050698
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journal_title:Archives of virology
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doi:10.1007/s00705-002-0954-8
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journal_title:Archives of virology
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journal_title:Archives of virology
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journal_title:Archives of virology
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doi:10.1007/BF01309681
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journal_title:Archives of virology
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journal_title:Archives of virology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/BF01319810
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journal_title:Archives of virology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/BF01310704
更新日期:1990-01-01 00:00:00
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journal_title:Archives of virology
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journal_title:Archives of virology
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journal_title:Archives of virology
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