Abstract:
:Several monoclonal antibodies recognizing distinct antigenic determinants in A-type inclusion bodies (ATIB) induced by cowpox virus (CPV) were obtained to examine the cross-reactivity among various strains of poxviridae, comprising CPV, ectromelia virus (EV), vaccinia virus (VV) and Shope fibroma virus (SFV). The monoclonal antibodies were classified into at least 3 groups on the basis of the results of an immunofluorescence test and immunoblotting; i. e., strain-specific, CPV and EV-specific and Orthopoxvirus (CPV, EV and VV)-specific antibodies. Differences were found between the antigenic determinants of ATIB of LB strains (LB red and LB white) and other strains (Amsterdam, 53, 58 and 60) of CPV and also between those of ATIB of CPV and EV. An interesting finding was that VV also produces the antigen analogous to that associated with ATIB in CPV- and EV-infected cells despite the absence of morphologically defined ATIB.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Kitamoto N,Tanimoto S,Hiroi K,Miyamoto H,Wakamiya N,Ueda S,Kato Sdoi
10.1007/BF01314294subject
Has Abstractpub_date
1986-01-01 00:00:00pages
357-66issue
3-4eissn
0304-8608issn
1432-8798journal_volume
91pub_type
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