Antibodies that cross-neutralize the tier-2 pseudoviruses are produced in antiretroviral-naïve HIV-1-infected children from northern India.

Abstract:

:In this cross-sectional study, we evaluated the efficiency of the plasma of 38 antiretroviral-naïve HIV-1-infected children from northern India against a standard panel of pseudoviruses (3 clade C and 3 clade B) by TZM-bl assay. Neutralization potential was observed to a variable extent, with a potency ranging up to reciprocal ID(50) titers of 1967. Cross-neutralization was observed in 28.9 % (11/38) of the children. There was a significant positive correlation between viremia and neutralization efficiency against two of the viruses studied (Du172 r = 0.49; p = 0.007 and RHPA r = 0.47; p = 0.01), suggesting that persistent antigenic stimulation is necessary for the generation of broadly neutralizing antibody responses in these children. Further mapping of the epitope specificities of the neutralization determinants in the polyclonal plasma would provide important information for immunogen design.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Prakash SS,Andrabi R,Kumar R,Lodha R,Kabra SK,Vajpayee M,Luthra K

doi

10.1007/s00705-012-1357-0

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

1797-801

issue

9

eissn

0304-8608

issn

1432-8798

journal_volume

157

pub_type

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