Abstract:
:In this cross-sectional study, we evaluated the efficiency of the plasma of 38 antiretroviral-naïve HIV-1-infected children from northern India against a standard panel of pseudoviruses (3 clade C and 3 clade B) by TZM-bl assay. Neutralization potential was observed to a variable extent, with a potency ranging up to reciprocal ID(50) titers of 1967. Cross-neutralization was observed in 28.9 % (11/38) of the children. There was a significant positive correlation between viremia and neutralization efficiency against two of the viruses studied (Du172 r = 0.49; p = 0.007 and RHPA r = 0.47; p = 0.01), suggesting that persistent antigenic stimulation is necessary for the generation of broadly neutralizing antibody responses in these children. Further mapping of the epitope specificities of the neutralization determinants in the polyclonal plasma would provide important information for immunogen design.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Prakash SS,Andrabi R,Kumar R,Lodha R,Kabra SK,Vajpayee M,Luthra Kdoi
10.1007/s00705-012-1357-0subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1797-801issue
9eissn
0304-8608issn
1432-8798journal_volume
157pub_type
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