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Genotypic analysis and latent membrane protein 1 expression of Epstein-Barr virus in extranodal NK/T-cell lymphoma from Northern Chinese patients.

Abstract：

:As the most common NK/T-cell lymphoma in Asian countries, extranodal NK/T-cell lymphoma, nasal type (ENKTL), has unique clinical features and a strong association with Epstein-Barr virus (EBV). In order to gain a preliminary understanding of the relationship between ENKTL and EBV, we performed genotypic analysis of EBV and investigated LMP1 expression in extranodal NK/T-cell lymphoma. Our study shows that ENKTL is an EBV-associated malignancy and that A, C and F are the predominant EBV genotypes in northern China. LMP1 expression is stronger in extranasal sites than nasal sites, and the expression level is strongly correlated to ENKTL and may play an important role in the development of ENKTL.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Wang H,Li H,Xing X,Zhao C,Luo B

doi

10.1007/s00705-015-2451-x

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

2071-4

issue

8

eissn

0304-8608

issn

1432-8798

journal_volume

160

pub_type

杂志文章

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