Effect of DNA polymerase inhibitors on the replication of human cytomegalovirus. Brief report.

Abstract:

:Aphidicolin, a specific inhibitor of cellular DNA polymerase alpha and of viral DNA polymerase, inhibits production of infectious virus and cellular and viral DNA synthesis of human cytomegalovirus (HCMV)-infected cells. On the other hand, 2',3'-dideoxynucleosides, inhibitors of DNA polymerases beta and gamma, do not affect HCMV replication. The data show that the alpha DNA polymerases of either viral or cellular origin are required for viral DNA synthesis, and cannot be substituted by the cellular DNA polymerase beta and gamma.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Gönczöl E,Plotkin SA

doi

10.1007/BF01310559

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

129-34

issue

1-2

eissn

0304-8608

issn

1432-8798

journal_volume

84

pub_type

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