Abstract：
:Different patterns of disease were observed among 11 chimpanzees who were inoculated intravenously with hepatitis E virus (HEV) positive fecal specimens from four different outbreaks (Nepal 1981, Uzbekistan 1981, Pakistan 1985, and Mexico 1986). Five chimpanzees had marginal or no liver enzyme elevations within 70 days of inoculation. Two of the chimpanzees had limited viremia, but did not produce detectable antibody. The four remaining chimpanzees had liver enzyme elevations, viral shedding, viremia, seroconversion to anti-HEV, and detectable HEV antigen in liver biopsy specimens. These results may reflect the range of infection patterns that develop in humans after natural exposure to the HEV.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
McCaustland KA,Krawczynski K,Ebert JW,Balayan MS,Andjaparidze AG,Spelbring JE,Cook EH,Humphrey C,Yarbough PO,Favorov MO,Carson D,Bradley DW,Robertson BHdoi
10.1007/s007050070065keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
1909-18issue
9eissn
0304-8608issn
1432-8798journal_volume
145pub_type
杂志文章abstract：:Molecular epidemiology can be used to identify human immunodeficiency virus (HIV) transmission clusters, usually using pol sequence for analysis. In the present study, we explored appropriate parameters to construct a simple network using HIV env and gag sequences instead of pol sequences for constructing a phylogenet...
journal_title：Archives of virology
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journal_title：Archives of virology
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pub_type： 杂志文章
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