Abstract:
:Antibody-like molecules consisting of the human CD 4 extracellular domain fused to human IgG1 heavy chain constant regions were genetically constructed and expressed in a BHK cell stable transfectant. Purified chimeric antibodies bound to HIV particles as it was shown by immuno electron microscopy, inhibited fusions of HIV-1-infected cells with uninfected cells, neutralized HIV-1, and were able to inhibit the spread of a cellular HIV-1 infection in CD 4+ cells. Plaque reduction assays with CD 4(+)-transfected Hela-cells showed a comparable inhibition of HIV-1 and HIV-2. Inhibitory functions were enhanced in the presence of complement. HIV-1- and HIV-2-infected CD 4+ cells were efficiently lysed by a slow, complement-dependent mechanism, whereas uninfected CD 4+ cells and HLA-DR+ cells were not affected.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Gregersen JP,Mehdi S,Gelderblom H,Zettlmeissl Gdoi
10.1007/BF01310503subject
Has Abstractpub_date
1990-01-01 00:00:00pages
29-43issue
1-2eissn
0304-8608issn
1432-8798journal_volume
111pub_type
杂志文章abstract::Electropherotypes (ET), serotypes, and subgroups of equine rotaviruses isolated from foals in Japan were determined. The ETs of 136 isolates from 1981 through to 1991 were divided into six groups: ET-A-ET-F. The ET-A, -B, -C, -D, -E, and -F were present in 3, 1, 121, 9, 1, and 1 strains, respectively. Representative v...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01379088
更新日期:1993-01-01 00:00:00
abstract::In 1991 and 1992, H1N2 influenza A viruses were isolated from the lungs of pigs with overt signs of respiratory disease at farms in the Chiba and Kanagawa prefectures of Japan. To determine the genetic origin of these isolates, we phylogenetically analyzed partial nucleotide sequences of their genes. The results indic...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050050415
更新日期:1998-01-01 00:00:00
abstract::In this study, a novel mycovirus designed Colletotrichum gloeosporioides ourmia-like virus 1 (CgOLV1) was isolated from a filamentous phytopathogenic fungus, Colletotrichum gloeosporioides. The virus has a genome of 2,516 nucleotides and contains a large open reading frame (ORF) encoding an RNA-dependent RNA polymeras...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-019-04346-2
更新日期:2019-10-01 00:00:00
abstract::Molecular epidemiology can be used to identify human immunodeficiency virus (HIV) transmission clusters, usually using pol sequence for analysis. In the present study, we explored appropriate parameters to construct a simple network using HIV env and gag sequences instead of pol sequences for constructing a phylogenet...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-017-3485-z
更新日期:2017-11-01 00:00:00
abstract::An F35L mutation in the N-terminal domain of the polymerase acidic protein (PA-Nter), which contains the active site of the endonuclease, has been reported to result in higher polymerase activity in mouse-adapted strains of the 2009 pandemic influenza A H1N1 virus. We modeled wild and mutant complexes of uridine 5'-mo...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-017-3681-x
更新日期:2018-04-01 00:00:00
abstract::In this study, we obtained the whole genomes of three porcine bocaparvovirus (PBoV) strains (GD6, GD10, and GD23) by polymerase chain reaction. Sequence analysis showed that all three field strains belonged to PBoV group 3 (G3). The phylogenetic trees based on NS1, NP1, and VP1 differed to the extent that these PBoVs ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-017-3606-8
更新日期:2018-03-01 00:00:00
abstract::Hepatitis B virus (HBV) infection has a major effect on health care systems, with about one-third of the world's population currently infected with the virus. There is an effective vaccine against HBV, which contains a recombinant "surface antigen" produced in an expression vector. Vaccination has proved to be success...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-008-0206-7
更新日期:2008-01-01 00:00:00
abstract::Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV). Although SFTS originated in China, it is an emerging infectious disease with prevalence confirmed in Japan, Korea, and Vietnam. The full-length genomes of 51 Korean SFTSV isolates from 2013 to 2016 were sequenced, and the sequences wer...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-020-04733-0
更新日期:2020-11-01 00:00:00
abstract::The nucleotide sequence of the coat protein cistron of an Austrian isolate of grapevine fanleaf virus (GFLV-FC) from Vitis vinifera cv. French Colombard was determined. It shows small differences at the RNA level as well as at the protein level compared to the sequences of already published grapevine fanleaf virus str...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01309730
更新日期:1995-01-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-012-1355-2
更新日期:2012-10-01 00:00:00
abstract::Complete nucleotide sequences of cytoplasmic inclusion (CI) genes of two strains of potato virus Y (PVY) were determined from six polymerase chain reaction (PCR)-amplified cDNA clones. The size of the CI genes of both ordinary (PVY-O) and necrotic strains (PVY-T13) was 1902 nucleotides, with a sequence homology of 83....
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01309785
更新日期:1993-01-01 00:00:00
abstract::Non-infectious hemagglutinating particles of rabies virus accumulated in the fluid phase of chick embryo cell cultures at 6 days post-infection, though they were undetectable at 4 days. They were characterized as looped filaments resembling viral envelope as revealed by electron microscopy. Another form of hemagglutin...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01317937
更新日期:1976-01-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-007-1083-1
更新日期:2008-01-01 00:00:00
abstract::Human astrovirus (HAstV) infections were confirmed in 17 (1.5%) of 1153 children and adults with diarrhea, from different regions of Korea, by testing their stool samples by reverse transcription-polymerase chain reaction using primers targeted to partial ORF 1a. Genotypes of isolates were determined by sequencing the...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-002-0844-0
更新日期:2002-09-01 00:00:00
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journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01718312
更新日期:1996-01-01 00:00:00
abstract::Between 2005 and 2011, 23 lineages of circulating vaccine-derived polioviruses (cVDPVs) were detected in Nigeria with nonstructural region (NSR) of non-polio enterovirus C (NPEV-C) origin. However, no information exists on NPEV-C strains recombining with oral poliovirus type 2 vaccine strains (OPV2) to make type 2 cVD...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-014-2322-x
更新日期:2015-03-01 00:00:00
abstract::Infectious laryngotracheitis (ILT), caused by infectious laryngotracheitis virus (ILTV), is an Office International des Epizooties (OIE) notifiable disease. However, we have not clearly understood the dynamic distribution, tissue tropism, pathogenesis, and replication of ILTV in chickens. In this report, we investigat...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-012-1414-8
更新日期:2013-03-01 00:00:00
abstract::Mengovirus, extracted from infected L-cell cultures with Freon 113 and concentrated from the aqueous phase with polyethyleneglycol, was chromatographed on protein-coated controlled pore glass (CPG). The covalent binding of protein to CPG is described. Further purification and concentration of mengovirus was achieved b...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01315283
更新日期:1978-01-01 00:00:00
abstract::Scutellaria baicalensis Georgi, a Chinese herbal decoction, has been used for the treatment of the common cold, fever and influenza virus infections. In previous studies, we found that oral administration of baicalein resulted in the inhibition of influenza A virus replication in vivo, which was linked to baicalin in ...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-014-2192-2
更新日期:2014-12-01 00:00:00
abstract::In February 2019, following the annual taxon ratification vote, the order Bunyavirales was amended by creation of two new families, four new subfamilies, 11 new genera and 77 new species, merging of two species, and deletion of one species. This article presents the updated taxonomy of the order Bunyavirales now accep...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-019-04253-6
更新日期:2019-07-01 00:00:00
abstract::Novel protoparvoviruses genetically related to human and non-human primate bufaviruses (BuVs) have been detected recently in respiratory and enteric specimens collected from dogs and cats. In this study, by molecular screening of archival collections of faecal samples from wolves and foxes, we detected BuVs with a rat...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-019-04304-y
更新日期:2019-09-01 00:00:00
abstract::Strawberry crinkle disease is one of the major diseases that threatens strawberry production. Although the biological properties of the agent, strawberry crinkle virus (SCV), have been thoroughly investigated, its complete genome sequence has never been published. Existing RT-PCR-based detection relies on a partial se...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-018-3860-4
更新日期:2018-09-01 00:00:00
abstract::The nonstructural rotavirus protein NSP1 binds specifically to viral mRNAs and to interferon regulatory factor 3 (IRF3), inducing IRF3 degradation through a proteasome-dependent pathway. By using a vaccinia virus expression system in mammalian cells, we found that the yield of NSP1 was 8- and 13-fold lower than the vi...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-006-0850-8
更新日期:2007-02-01 00:00:00
abstract::Immunoblot analysis of apple latent spherical cheravirus (ALSV)-infected leaves using a polyclonal antibody against the 21 C-terminal amino acids of a 53 K/42 K movement protein (MP) showed that a protein with an Mr of 42 kDa (42KP) is the dominant form found in vivo, which could indicate that the second AUG is used a...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-005-0689-4
更新日期:2006-05-01 00:00:00
abstract::To investigate the genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV) in Northern Ireland, the ORF5 gene from nine field isolates was sequenced and phylogenetically analysed. The results revealed relatively high diversity amongst isolates, with 87.6-92.2% identity between farms at the nuc...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-018-3886-7
更新日期:2018-10-01 00:00:00
abstract::The Chinese hog cholera lapinized virus (HCLV), also called the "Chinese strain" or "C-strain" of classical swine fever virus (CSFV), was developed in China in the 1950s. There are uncertainties about the genetic heterogeneity and origin of this vaccine virus. The objectives of this study were to investigate the genet...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s00705-011-0948-5
更新日期:2011-06-01 00:00:00
abstract::Purified DNA from 45 isolates of suis herpes virus 1 (SHV1) collected between 1980 and 1987 from clinical outbreaks of Aujeszky's disease on French farms was compared by restriction fragment pattern (RFP) analysis. The BamHI generated RFPs were found to be distinguishable, confirming RFP analysis as a potential epidem...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01323161
更新日期:1990-01-01 00:00:00
abstract::We have recently demonstrated the geographic isolation of rice tungro bacilliform virus (RTBV) populations in the tungro-endemic provinces of Isabela and North Cotabato, Philippines. In this study, we examined the genetic structure of the virus populations at the tungro-outbreak sites of Lanao del Norte, a province ad...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/s007050070013
更新日期:2000-01-01 00:00:00
abstract::Mouse cell lines (L, NIH3T3, and RMA cells) infected with the Edmonston strain of measles virus (MV) did not exhibit cytopathic effects (CPE), consistent with the finding that mice are not susceptible to MV. Northern blot analysis, however, revealed that MV genes were transcribed in infected L and NIH3T3 cells, althou...
journal_title:Archives of virology
pub_type: 杂志文章
doi:10.1007/BF01310037
更新日期:1994-01-01 00:00:00
abstract::Beet necrotic yellow vein virus RNA 1 contains a single long ORF corresponding to the theoretical translation product of 237 kDa which contains the information necessary for replication of the viral genome. This ORF contains a putative papain-like proteinase domain which has been localized, on the basis of sequence al...
journal_title:Archives of virology
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00