Genetic diversity and evolutionary history of Korean isolates of severe fever with thrombocytopenia syndrome virus from 2013-2016.

Abstract:

:Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV). Although SFTS originated in China, it is an emerging infectious disease with prevalence confirmed in Japan, Korea, and Vietnam. The full-length genomes of 51 Korean SFTSV isolates from 2013 to 2016 were sequenced, and the sequences were deposited into a public database (GenBank) and analyzed to elucidate the phylogeny and evolution of the virus. Although most of the Korean SFTSV isolates were closely related to previously reported Japanese isolates, some were closely related to previously reported Chinese isolates. We identified one Korean strain that appears to have resulted from multiple inter-lineage reassortments. Several nucleotide and amino acid variations specific to the Korean isolates were identified. Future studies should focus on how these variations affect virus pathogenicity and evolution.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Yun MR,Ryou J,Choi W,Lee JY,Park SW,Kim DW

doi

10.1007/s00705-020-04733-0

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

2599-2603

issue

11

eissn

0304-8608

issn

1432-8798

pii

10.1007/s00705-020-04733-0

journal_volume

165

pub_type

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