Modulation of lethal and persistent rat parvovirus infection by antibody.

Abstract:

:Two day-old athymic (rnu/rnu) and euthymic (rnu/+) rat pups nursing immune or non-immune dams were inoculated oronasally with the Yale strain of rat virus (RV-Y). All athymic and euthymic pups (57/57) from immune dams remained clinically normal, whereas 51 of 66 athymic and euthymic pups from non-immune dams died within 30 days. Infectious RV was detected by explant culture in 12 of 15 surviving pups of both genotypes from non-immune dams 30 days after inoculation, but in none of the 57 surviving pups from immune dams. RV-Y DNA was detected by Southern blotting in kidneys of surviving athymic pups from non-immune dams but was not detected in pups from immune dams. Euthymic pups from immune dams appeared not to produce endogenous antibody to RV after virus challenge, whereas euthymic pups from non-immune dams produced high-titered RV immune serum. Pups of both genotypes given immune serum prior to or with RV were fully protected from disease and persistent infection, whereas pups given immune serum 24 hours after RV were partially protected. These studies show that RV antibody offers significant protection against lethal and persistent RV infection.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Gaertner DJ,Jacoby RO,Paturzo FX,Johnson EA,Brandsma JL,Smith AL

doi

10.1007/BF01311299

keywords:

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

1-9

issue

1-2

eissn

0304-8608

issn

1432-8798

journal_volume

118

pub_type

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